dc.creator | Davis, Stacey | |
dc.creator | Hook, Magnus A. O. | |
dc.date.accessioned | 2019-06-17T16:59:05Z | |
dc.date.available | 2019-06-17T16:59:05Z | |
dc.date.issued | 2004-12-28 | |
dc.identifier.uri | https://hdl.handle.net/1969.1/176774 | |
dc.description.abstract | A method of achieving safe and effective treatment or prevention of potentially harmful blood clots, or in inhibiting the coagulation of blood when so desired such as during a wide array of disease conditions including stroke, myocardial infarction, sickle-cell crisis and venous thrombosis, is provided by the administration of a fibrinogen-binding protein capable of binding at the N-terminal Bβ chain of fibrinogen, such as SdrG or Fbe, or their respective binding regions such as the A domain. In addition, compositions comprising effective amounts of the fibrinogen-binding proteins are also provided. The present anti-coagulation compositions have been shown to inhibit thrombin-induced fibrin clot formation by interfering with the release of fibrinopeptide B and the resulting anti-coagulation effects can be achieved without potential for causing or exacerbating unwanted side effects such as thrombocytopenia associated with prior art anticoagulants such as heparin. | en |
dc.language | eng | |
dc.publisher | United States. Patent and Trademark Office | |
dc.rights | Public Domain (No copyright - United States) | en |
dc.rights.uri | http://rightsstatements.org/vocab/NoC-US/1.0/ | |
dc.title | Method and compositions for inhibiting thrombin-induced coagulation | en |
dc.type | Utility patent | en |
dc.format.digitalOrigin | reformatted digital | en |
dc.description.country | US | |
dc.contributor.assignee | The Texas A&M University System University | |
dc.identifier.patentapplicationnumber | 10/142935 | |
dc.subject.uspcprimary | 424/94.63 | |
dc.subject.uspcother | 424/94.67 | |
dc.subject.uspcother | 514/13.6 | |
dc.subject.uspcother | 514/13.7 | |
dc.subject.uspcother | 514/14.7 | |
dc.subject.uspcother | 530/382 | |
dc.date.filed | 2002-05-13 | |
dc.publisher.digital | Texas A&M University. Libraries | |
dc.subject.cpcprimary | A61P 9/10 | |
dc.subject.cpcprimary | A61K 38/482 | |
dc.subject.cpcprimary | A61P 7/02 | |
dc.subject.cpcprimary | A61K 38/164 | |
dc.subject.cpcprimary | C07K 14/31 | |
dc.subject.cpcprimary | A61K 38/482 | |
dc.subject.cpcprimary | A61K 2300/00 | |