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dc.creatorPatti, Joseph M.
dc.creatorFoster, Timothy J.
dc.creatorHook, Magnus
dc.date.accessioned2019-06-17T16:58:11Z
dc.date.available2019-06-17T16:58:11Z
dc.date.issued2004-02-17
dc.identifier.urihttp://hdl.handle.net/1969.1/176749
dc.description.abstractA method and composition for the passive immunization of patients infected with or susceptible to infection from Staphylococcus bacteria such as S. aureus and S. epidermidis infection is provided that includes the selection or preparation of a donor plasma pool with high antibody titers to carefully selected Staphylococcus adhesins or MSCRAMMs, or fragments or components thereof, or sequences with substantial homology thereto. The donor plasma pool can be prepared by combining individual blood or blood component samples which have higher than normal titers of antibodies to one or more of the selected adhesins or other proteins that bind to extracellular matrix proteins, or by administering carefully selected proteins or peptides to a host to induce the expression of desired antibodies, and subsequently recovering the enhanced high titer serum or plasma pool from the treated host. In either case, the donor plasma pool is preferably purified and concentrated prior to intravenous introduction into the patient, and the present invention is advantageous in that a patient can be immunized against a wide variety of potentially dangerous staphylococcal infections. Kits for identifying potential donor with high titers of the selected adhesins are also provided. The present invention thus provides methods and compositions which can be highly effective against infections associated with Staphylococcus bacteria.en
dc.languageeng
dc.publisherUnited States. Patent and Trademark Office
dc.rightsPublic Domain (No copyright - United States)en
dc.rights.urihttp://rightsstatements.org/vocab/NoC-US/1.0/
dc.titleStaphylococcal immunotherapeutics via donor selection and donor stimulationen
dc.typeUtility patenten
dc.format.digitalOriginreformatted digitalen
dc.description.countryUS
dc.contributor.assigneeInhibitex, Inc.
dc.contributor.assigneeThe, Provost Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin
dc.contributor.assigneeThe Texas A&M University System
dc.identifier.patentapplicationnumber09/386960
dc.subject.uspcprimary424/130.1
dc.subject.uspcother424/137.1
dc.subject.uspcother424/150.1
dc.subject.uspcother424/185.1
dc.subject.uspcother530/387.1
dc.subject.uspcother530/387.5
dc.subject.uspcother530/388.2
dc.subject.uspcother530/388.4
dc.date.filed1999-08-31
dc.publisher.digitalTexas A&M University. Libraries


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