Decorin binding protein compositions
Abstract
Disclosed are the dbp gene and dbp-derived nucleic acid segments from Borrelia burgdorferi, the etiological agent of Lyme disease, and DNA segments encoding dbp from related borrelias. Also disclosed are decorin binding protein compositions and methods of use. The DBP protein and antigenic epitopes derived therefrom are contemplated for use in the treatment of pathological Borrelia infections, and in particular, for use in the prevention of bacterial adhesion to decorin. DNA segments encoding these proteins and anti-(decorin binding protein) antibodies will also be of use in various screening, diagnostic and therapeutic applications including active and passive immunization and methods for the prevention of Borrelia colonization in an animal. These DNA segments and the peptides derived therefrom are contemplated for use in the preparation of vaccines and, also, for use as carrier proteins in vaccine formulations, and in the formulation of compositions for use in the prevention of Lyme disease.
Subject
514/2.4530/350
530/806
530/825
A61P 37/00
A61P 31/04
C07K 14/20
A61K 39/00
Y02A 50/476
A01K 2217/05
A61K 38/00
Y10S 530/806
Y10S 530/825
Y02A 50/401
Y02A 50/30
Collections
Citation
Guo, Betty; Hook, Magnus (2001). Decorin binding protein compositions. United States. Patent and Trademark Office; Texas A&M University. Libraries. Available electronically from https : / /hdl .handle .net /1969 .1 /176662.