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    DbpA compositions

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    6214355.pdf (7.052Mb)
    Date
    2001-04-10
    Author
    Guo, Betty P.
    Hook, Magnus
    Metadata
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    Abstract
    Disclosed are the dbp gene and dbp-derived nucleic acid segments from Borrelia burgdorferi, the etiological agent of Lyme disease, and DNA segments encoding dbp from related borrelias. Also disclosed are decorin binding protein compositions and methods of use. The DBP protein and antigenic epitopes derived therefrom are contemplated for use in the treatment of pathological Borrelia infections, and in particular, for use in the prevention of bacterial adhesion to decorin. DNA segments encoding these proteins and anti-(decorin binding protein) antibodies will also be of use in various screening, diagnostic and therapeutic applications including active and passive immunization and methods for the prevention of Borrelia colonization in an animal. These DNA segments and the peptides derived therefrom are contemplated for use in the preparation of vaccines and, also, for use as carrier proteins in vaccine formulations, and in the formulation of compositions for use in the prevention of Lyme disease.
    URI
    https://hdl.handle.net/1969.1/176659
    Subject
    424/234.1
    514/2.8
    530/350
    530/388.4
    C07K 14/20
    A61P 31/04
    A61P 37/00
    Y02A 50/401
    Y10S 530/825
    Y02A 50/30
    Y10S 530/806
    A01K 2217/05
    A61K 38/00
    A61K 39/00
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    • Texas A&M University Patents
    Citation
    Guo, Betty P.; Hook, Magnus (2001). DbpA compositions. United States. Patent and Trademark Office; Texas A&M University. Libraries. Available electronically from https : / /hdl .handle .net /1969 .1 /176659.

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