Emulsions of perfluoro compounds as solvents for nitric oxide (NO)
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The present invention involves perfluoro compound emulsions including nitric oxide, their preparation and their use. These emulsions provide a new source of nitric oxide. Such nitric oxide-containing emulsions may be used for the administration of nitric oxide to individuals in need thereof. Individuals in need of nitric oxide administration can include those suffering from hypertension, preeclampsia and a number of other situations where an increased blood flow, for example, is desirable. In addition, given the long use of perfluoro compound emulsions as blood substitutes, the present invention provides a relatively safe mode for administering and distributing nitric oxide-without potential negative side effects such as toxicities due to drug metabolites.
Garfield R. E.; Balaban A. T.; Seitz W. A. (1999). Emulsions of perfluoro compounds as solvents for nitric oxide (NO). United States. Patent and Trademark Office; Texas A&M University. Libraries. Available electronically from