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dc.contributor.advisorRees, Terry
dc.creatorKarim, Naveen Manori
dc.date.accessioned2017-08-21T14:37:57Z
dc.date.available2019-05-01T06:07:48Z
dc.date.created2017-05
dc.date.issued2017-05-09
dc.date.submittedMay 2017
dc.identifier.urihttp://hdl.handle.net/1969.1/161437
dc.description.abstractThe aim of this study was to evaluate the clinical performance of an antioxidant (AO) gel used to treat patients suffering from drug-induced xerostomia compared to a placebo gel. The study was a double-blind, prospective, randomized clinical trial. It included adult subjects with drug-induced xerostomia (n=43). Unstimulated whole salivary flow was measured using the spit technique. A Xerostomia Visual Analog Scale (XVAS) was used to assess symptoms of xerostomia and a patient satisfaction survey (PSS) to measure satisfaction with the gel. XVAS survey evaluations were performed at baseline, 2 weeks, 4 weeks, 6 weeks, 8 weeks, and 10 weeks. PSS evaluations were performed at 2 weeks, 4 weeks, 8 weeks, and 10 weeks. There was a crossover and wash out period from 4 to 6 weeks. Saliva was collected at each visit to measure Total Antioxidant Capacity (TAC). 43 patients were randomized into two groups, active or placebo. Symptoms improved in the treatment group (n=21) compared to the control group (n=15) after 10 weeks in the following PSS domains: Ability to eat, p<.05 at week 2, and Soothing effect, p<.05 at week 4. A significant difference was identified between the groups with the XVAS survey regarding the soothing effect after using the AO dry mouth gel (P<0.05). TAC analysis did not show any significant correlation with the use of gel. The topical application of an antioxidant gel containing phloretin and ferulic acid compared to a placebo improved symptoms of drug-induced xerostomia. However, no significant anti-oxidant effect was found using TAC analysis.en
dc.format.mimetypeapplication/pdf
dc.language.isoen
dc.subjectDry mouthen
dc.subjectxerostomiaen
dc.subjectTACen
dc.subjectSalivary flowen
dc.subjectVASen
dc.titlePatients Satisfaction Survey and Total Antioxidant Capacity in Patients with Xerostomia Compared to a Placebo Group: An Evaluation of an Antioxidant Gel for Management of Xerostomiaen
dc.typeThesisen
thesis.degree.departmentCollege of Dentistryen
thesis.degree.disciplineOral Biologyen
thesis.degree.grantorTexas A & M Universityen
thesis.degree.nameMaster of Scienceen
thesis.degree.levelMastersen
dc.contributor.committeeMemberOpperman, Lynne
dc.contributor.committeeMemberCheng, Lisa
dc.contributor.committeeMemberSvoboda, Kathy
dc.contributor.committeeMemberPlemons, Jacqueline
dc.contributor.committeeMemberRossmann, Jeffrey
dc.type.materialtexten
dc.date.updated2017-08-21T14:37:57Z
local.embargo.terms2019-05-01
local.etdauthor.orcid0000-0002-4502-2954


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