Direct Exercise Metabolite Inhibition of Breast Cancer Cell Growth

Abstract

The purpose of this study is to determine the effect of lactate released from contracting muscle on breast cancer cell growth. It is well known that during exercise, contracting muscle releases many different substances, including hydrogen ions, lactate, adenosine diphosphate, ammonia, as well as many muscle specific factors. Current research supports the hypothesis that a muscle specific factor directly suppresses breast tumor growth. Likely candidates include a protein or exercise related metabolite. This research will specifically address lactate’s role in breast cancer growth.