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dc.contributor.advisorMeagher, Mary
dc.creatorSieve, Amy Nicole
dc.date.accessioned2005-02-17T21:05:22Z
dc.date.available2005-02-17T21:05:22Z
dc.date.created2004-12
dc.date.issued2005-02-17
dc.identifier.urihttp://hdl.handle.net/1969.1/1558
dc.description.abstractMultiple Sclerosis (MS) is the most common demyelinating condition of the central nervous system (CNS), resulting in paralysis and death. The etiology of MS is unknown. However, genetics, exposure to a pathogen, psychological stress and gender are all implicated in the onset and progression of the disease. An animal model of MS, Theiler’s virus (TMEV) infection, causes a biphasic disease. An early CNS viral infection, if allowed to persist within the CNS, is followed by a chronic CNS autoimmune demyelinating condition that is similar to MS. The development of Theiler’s Virus Induced Demyelination (TVID) is under genetic control: SJL mice are highly susceptible to viral persistence and TVID while CBA mice have an intermediate susceptibility. Chronic restraint stress (RST) administered during the first four weeks of TMEV infection influenced the subsequent development of TVID differentially across strain and sex of mice. TVID was exacerbated by RST in male and female SJL mice, but in the CBA strain, TVID was alleviated by RST in male mice only. This pattern of results in SJL and CBA mice could be seen in the chronic phase of TVID on multiple dependent measures: body weights, behavioral signs of the chronic phase, rotarod performance (an automated measure of motor abilities), and inflammation, demyelination, and axonal loss within the spinal cord. The exacerbation of TVID in SJL mice provides some of the first experimental evidence that coincides with reports of stress precipitating the onset of MS in human patients. The sex dependent alleviation of TVID in CBA mice illustrates the complex interaction between genetic predisposition, gender, stress, and exposure to a pathogen that has been proposed for the development of MS.en
dc.format.extent4851088 bytesen
dc.format.mediumelectronicen
dc.format.mimetypeapplication/pdf
dc.language.isoen_US
dc.publisherTexas A&M University
dc.subjectstressen
dc.subjectMultiple Sclerosisen
dc.subjectsex differencesen
dc.subjectTheiler's Virusen
dc.subjectdemyelinationen
dc.subjectautoimmunityen
dc.titleThe effects of psychological stress on an animal model of multiple sclerosis, Theiler's virus induced demyelinationen
dc.typeBooken
dc.typeThesisen
thesis.degree.departmentPsychologyen
thesis.degree.disciplinePsychologyen
thesis.degree.grantorTexas A&M Universityen
thesis.degree.nameDoctor of Philosophyen
thesis.degree.levelDoctoralen
dc.contributor.committeeMemberWelsh, C. Jane
dc.contributor.committeeMemberSohrabji, Farida
dc.contributor.committeeMemberWelsh, Thomas
dc.type.genreElectronic Dissertationen
dc.type.materialtexten
dc.format.digitalOriginborn digitalen


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