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dc.contributor.advisorKlutke, Georgia-Ann
dc.creatorLi, Ang
dc.date.accessioned2015-01-09T20:25:35Z
dc.date.available2015-01-09T20:25:35Z
dc.date.created2014-05
dc.date.issued2014-05-19
dc.date.submittedMay 2014
dc.identifier.urihttp://hdl.handle.net/1969.1/152571
dc.description.abstractCertain diseases comprise an initial asymptomatic period during which they can be identified only by a screening test. In many such cases, early detection translates into benefits of more treatment options and potentially better prognosis. In this dissertation, we consider the optimal policy to screen for a preclinical disease while under limited budget. Our objective is to place any given number of screening epochs over an individual's lifetime, such that the probability of identifying the disease while preclinical is maximized. We make mild assumptions about the sojourn times of the individual in the healthy and preclinical states, and we consider the possibility of fallible screening tests. We show that a unique optimal sequence of screening times exist for our model, and that it can be quickly found by any greedy-search algorithm. We further conduct numerical experimentations by which we identify sensitive model inputs. We lastly apply our model to breast cancer screening using practical information and we investigate additional characteristics of this model.en
dc.format.mimetypeapplication/pdf
dc.language.isoen
dc.subjectpolicy modeling and public sector operations researchen
dc.subjectasymptomatic disease screeningen
dc.subjectnatural history modelen
dc.subjectstochastic modelsen
dc.subjectnonlinear optimizationen
dc.titleOptimal Screening for Preclinical Diseasesen
dc.typeThesisen
thesis.degree.departmentIndustrial and Systems Engineeringen
thesis.degree.disciplineIndustrial and Systems Engineeringen
thesis.degree.grantorTexas A & M Universityen
thesis.degree.nameDoctor of Philosophyen
thesis.degree.levelDoctoralen
dc.contributor.committeeMemberCline, Daren B.H.
dc.contributor.committeeMemberGautam, Natarajan
dc.contributor.committeeMemberCurry, Guy L.
dc.type.materialtexten
dc.date.updated2015-01-09T20:25:35Z
local.etdauthor.orcid0000-0002-6427-6829


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