| dc.description.abstract | Purpose: The purpose of this research was to quantify the number of blood vessels and nerves and mineral apposition rate (MAR) in native bone and compare it to the regenerate bone produced by bone transport distraction osteogenesis (BTDO).
Methods: Five adult foxhounds were subjected to the surgical removal of the anterior portion of the mandible. A bone transport reconstruction plate (BTRP-02, Craniotech ACR devices, LLC) device was used to transport the two segments created on each side of the mandible: One segment comprised an endodontically treated tooth, and the other was edentulous. After the bone transport distraction osteogenesis (BTDO) process was finished, 40-44 days of consolidation time was allowed before the dogs were sacrificed. The mandibles were resected and prepared for analysis. Histomorphometric and histologic analyses were performed for the regenerate and native bone.
Results: The histologic analysis showed no significant differences in the number of blood vessels (large or small) and nerves (large or small) between the native and regenerate bone. No significant differences were observed between the dentulous and edentulous regenerate bone. Confocal microscopy and Bioquant analysis showed significant differences (P≤ 0.05) in the MAR between the native bone and the regenerate bone, but no significant differences were observed between the dentate and edentulous regenerates.
Conclusion: The regenerate bone formed in the canine mandible by BTDO displayed a well-regenerated neurovascular complex within the alveolar canal, containing large and small blood vessels and nerves that were compared to those present in the native bone. Mineralization of the regenerate bone occurred at a rate higher than that of native bone.
Key words: Bone Transport, Distraction Osteogenesis, Blood Vessels, Nerves, Mineral Apposition Rate | en |
