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dc.creatorHinkley, Megan L
dc.date.accessioned2013-06-04T16:10:22Z
dc.date.available2013-06-04T16:10:22Z
dc.date.created2010-05
dc.date.issued2012-07-11
dc.date.submittedMay 2010
dc.identifier.urihttp://hdl.handle.net/1969.1/ETD-TAMU-2010-05-8153
dc.identifier.urihttp://hdl.handle.net/1969.1/148754
dc.description.abstractSalmonella species cause substantial morbidity, mortality, and disease burden globally with multiple clinical syndromes. A protective host defense to Salmonella infection requires both T-cell (cell-mediated) and B-cell (humoral) immune response. Current vesicle vaccine platforms include inactivated, non-replicating, or synthetic liposomes which do not produce a robust immune response because they lack foreign distinctness and complexity. Membrane vesicles (MVs), released in a conserved process by Gramnegative bacteria, are discrete, spherical nano-particles that are composed of outer membrane and periplasmic constituents including lipopolysaccharides and proteins. MVs are promising vaccine candidates for the following reasons: their intrinsic adjuvant properties, genetically malleability via the parental bacterial strain that can alter vaccine efficacy, a minimal production cost, and they are stable in powder form. As biologically derived but nonreplicating particles they are important in the vaccine strategy for immunocompromised populations. My findings reveal MVs posses important inflammatory properties that demonstrate a viable vaccine platform potential for Salmonella infection.en
dc.format.mimetypeapplication/pdf
dc.subjectSalmonellaen
dc.subjectmembrane vesiclesen
dc.subjectrobust immune responseen
dc.titleMembrane Vesicles as a Vaccine Platform For Salmonellaen
dc.typeThesisen
thesis.degree.departmentCollege of Agriculture and Life Sciencesen
thesis.degree.disciplineBiochemistryen
thesis.degree.grantorHonors and Undergraduate Researchen
thesis.degree.nameBachelor of Scienceen
dc.contributor.committeeMemberAlaniz, Robert C
dc.type.materialtexten
dc.date.updated2013-06-04T16:10:22Z


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