Browsing by Subject "x-ray crystallography"
Now showing items 1-4 of 4
-
(2008-08-03)The emergence of multidrug-resistant strains of Mycobacterium tuberculosis (Mtb) has intensified efforts to discover novel drugs for tuberculosis (TB) treatment. Targeting the persistent state of Mtb, a condition in which ...
-
(2011-10-21)Bacillus stearothermophilus phosphofructokinase (BsPFK) is a homotetramer that is allosterically inhibited by phosphoenolpyruvate (PEP), which binds along one dimer-dimer interface. The substrate, fructose-6-phosphate ...
-
(2021-04-12)Nearly half of clinically used antibiotics target ribosome, the vital translational machinery for bacterial survival. In this dissertation, we studied the translational regulation and antibiotic resistance in Mycobacterium ...
-
(2019-10-31)Iron-sulfur (Fe-S) clusters are inorganic cofactors found throughout all domains of life. These clusters are often ligated to proteins allowing Fe-S clusters to participate in a variety of essential processes such as ...