Browsing by Subject "tyrosine hydroxylase"
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(2011-10-21)Tyrosine hydroxylase (TyrH) is the first and rate-limiting enzyme of catecholamine synthetic pathway, and its regulation is critical for controlling catecholamine synthesis. The well recognized regulatory mechanisms are ...
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(1993)A conserved histidine residue at position 331 of rat tyrosine hydroxylase was changed to glutamine by site-directed mutagenesis. The mutant enzyme, TOH-H331Q, was expressed in E. coli with a pET3b-based vector. The level ...
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Studies of the relationship of protein structure to regulation and catalysis in tyrosine hydroxylase (Texas A&M University, 2007-09-17)Tyrosine hydroxylase (TyrH) catalyzes the rate-limiting step in the synthesis of the catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine. Phosphorylation of Ser40 of rat TyrH activates the enzyme by ...