Browsing by Subject "tuberculosis"
Now showing items 1-10 of 10
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(2019-01-14)Isocitrate lyase 1 & 2 are essential enzymes for Mycobacterium tuberculosis pathogenicity and antibiotic resistance, and thereby, are appealing targets for the treatment of latent tuberculosis. Since high-throughput screening ...
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TnSeq is a genetic method used to evaluate the essentiality of genes in bacteria, such as Mycobacterium tuberculosis. It uses random insertions by the Himar1 transposon and high throughput sequencing to determine the most ...
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(2014-12-17)The goal of this study was to develop drugs that exclusively affect pathogenic dihydrofolate reductase (DHFR) without causing harm to the human counterpart. To achieve that goal, a well-known dihydrofolate reductase (DHFR) ...
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(1997)The continued threat of tuberculosis (TB) to animals and humans is complicated by inefficient or ineffective methods of diagnosis and prevention. The high similarity among mycobacteria makes differentiation of strains and ...
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(2008-08-03)The emergence of multidrug-resistant strains of Mycobacterium tuberculosis (Mtb) has intensified efforts to discover novel drugs for tuberculosis (TB) treatment. Targeting the persistent state of Mtb, a condition in which ...
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(2018-08-06)Tuberculosis (TB) is the deadliest disease caused by a single organism, killing 1.7 million people in 2016. TB is especially deadly in immuno-compromised populations, including HIV-positive patients and children. In 2014, ...
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(2019-03-06)The cell wall is a common component found in nearly all bacteria. Long validated as a drug target for over half of all prescribed antibiotics, it continues to offer new sources for increasing that number ever further. ...
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(2011-08-08)Structural biology lays the molecular foundation for the modern field of life sciences. In this thesis, X-ray crystallography is the primary resource for atomic detail structural information and is the major technology ...
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(2009-05-15)Catalase-peroxidase (KatG) of Mycobacterium tuberculosis is a bifunctional heme enzyme that has been shown to play an important role in the activation of a first line drug, isoniazid (INH), used in the treatment of ...
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(2009-05-15)The increase of multi-drug resistant and extensively drug resistant tuberculosis (TB) cases makes it urgent to develop a new generation of TB drugs to counter resistance and shorten treatment. Structural biology, which ...