Browsing by Subject "protein engineering"
Now showing items 1-5 of 5
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Clostridioides difficile (C. difficile), the microbe responsible for Clostridioides difficile infection (CDI), is a common nosocomial infection that exerts its pathogenicity primarily by two toxins, TcdA and TcdB. Designed ...
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(Texas A&M University, 2004-09-30)Directed evolution studies were done with PTE for the enhancement of hydrolysis of both sarin and soman analogs. Particular attention was focused on the toxic SpRc and SpSc isomers of the soman analog, and the Sp isomer ...
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(2009-05-15)This study generated two cyanide dihydratase (CynD) mutants of Bacillus pumilus C1 with improved activity at higher pH by random mutagenesis. The purpose of this study was to create enzyme variants better suited to degrade ...
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(Texas A&M University, 2006-08-16)Staphylococcal leukocidin pores are formed by the obligatory interaction of two distinct polypeptides, one of class F and one of class S, making them unique in the family of β-barrel pore-forming toxins (β-PFTs). ...
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(2009-05-15)Environmental signals are sensed by membrane-spanning receptors that communicate with the cell interior. Bacterial chemoreceptors modulate the activity of the CheA kinase in response to binding of small ligands or upon ...