Browsing by Subject "peptidomimetics"
Now showing items 1-7 of 7
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(2020-12-04)Due to the worldwide prevalence of pesticide resistance in disease vectors, novel targets and corresponding reagents for alternative pest control are needed. Invertebrate neuropeptide G protein-coupled receptors (GPCRs) ...
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(2009-06-02)Over the years, the Burgess group has been focusing on the preparation and testing of small molecules that mimic protein secondary structures for protein-protein interactions. The most successful compounds made are C10 ...
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(Texas A&M University, 2007-04-25)In an effort to partially mimic the complex interaction between nerve growth factor (NGF) and its membrane-bound tyrosine kinase A receptor (TrkA), several small organic molecules with functionalities similar to the ...
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(2009-06-02)Solid-phase syntheses of two 14-membered ring peptidomimetics were done to determine whether or not a beta-turn structure can facilitate macrocyclization. NMR methods, together with CD and QMD calculations, do not fully ...
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(Texas A&M University, 2005-08-29)Quenched Molecular Dynamics (QMD) used to explore molecular conformations was developed to operate in Insight II platform for two simulation engines: CHARMm and Discover. Two scripts and procedures were written for molecular ...
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(2021-02-11)Small molecule probe development is pivotal in biomolecular science. Peptidomimetics are generally interesting if they resemble peptides or protein-fragments and display biological activities. To achieve this, it is desirable ...
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(2009-05-15)Copper-mediated alkyne-azide cycloadditions yield 1,4-disubstituted triazoles with high chemoselectivity that can be used in many ways. For instance, when alkyne or azido peptide units combine via this pathway the reaction ...