Browsing by Subject "lysis"
Now showing items 1-11 of 11
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(2018-05-03)Spanins are required for the last step in bacteriophage lysis: the disruption of the outer membrane. However, bioinformatic analysis has shown 15 percent of phages lack a spanin gene, which suggests an alternate mechanism ...
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(2009-05-15)In order to release progeny, bacteriophages must lyse the host cell by compromising the peptidoglycan layer. There are two known strategies of lysis: the holin-endolysin system and single gene lysis (SGL), which are dependent ...
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(Texas A&M University, 2005-11-01)The N-terminal hydrophobic domain of the phage P1 endolysin Lyz was found to facilitate the export of Lyz in a sec-dependent fashion, explaining the ability of Lyz to cause lysis of E.coli in the absence of the P1 holin. ...
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(2013-11-06)Bacteriophages infect and kill bacterial cells. During the infection cycle, a phage attaches to the host cell surface, then ejects its DNA into the cytoplasm, where its progenies are subsequently assembled. The final ...
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(2012-10-19)Like all phages, T4 requires a holin (T) to effect lysis. The lysis event depends on the temporally regulated action of T, which accumulates in the inner membrane (IM) until, at an allele-specific time, it triggers to ...
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(2011-08-08)Lysis of the host by bacteriophage 21 requires two proteins: the pinholin S21 (forms pinholes in the cytoplasmic membrane and controls lysis timing) and the endolysin (degrades the cell wall). S21 has a dual-start motif, ...
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(2013-09-26)The lambda lysis genes Rz and Rz1 play an important role at the final step of bacterial cell lysis. Rz encodes an integral inner membrane protein and Rz1 encodes an outer membrane lipoprotein. These two proteins form a ...
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(2010-07-14)Most bacteriophages release progeny virions at the end of the infection cycle by lysis of the host. Large phages with double-stranded DNA genomes use a multigene strategy based on holins, small membrane proteins, and ...
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(2016-08-01)Most of the large, double-stranded DNA (dsDNA) bacteriophages infecting Gram-negative hosts utilize multi-protein strategy to lyse the three layers of the host cell envelop: the inner membrane (IM), the peptidoglycan (PG), ...
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(2012-02-14)SAR endolysins are a recently discovered class of muralytic enzymes that are regulated by dynamic membrane topology. They are synthesized as enzymatically inactive integral membrane proteins during the phage infection cycle ...
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(2009-05-15)The timing of host lysis is the only decision made in the bacteriophage lytic cycle. To optimize timing, double-stranded DNA phages use a 2-component lysis system consisting of a muralytic enzyme, the endolysin, and a small ...