Browsing by Subject "TrkC"
Now showing items 1-4 of 4
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(2019-05-21)Cancer has become one of the biggest threats to human health. In most cases, cancer cells can be differentiated from normal tissues via the overexpression of certain cellular membrane proteins. Improved therapeutic effects ...
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(2012-07-16)Protein-protein interactions (PPIs) are attractive targets because of their therapeutic potential. One approach to design small molecules that can disrupt the PPIs is to use structural information of proteins. With this ...
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(2020-04-08)Targeted therapy for cancer is a hot topic in recent years. Small molecule pharmaceuticals have advantages relative to antibodies with respect to cell penetration and affordability. This dissertation focuses on the application ...
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(2015-06-15)This dissertation features a small molecule, non-peptidic, ligand designed to bind a cell surface receptor called tropomyosin receptor kinase C (TrkC). TrkC is overexpressed on various types of tumors including breast ...