Browsing by Subject "Telomerase"
Now showing items 1-5 of 5
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(2015-05-13)In eukaryotes the ends of chromosomes are constituted by nucleoprotein complexes termed telomeres. Telomeres represses a DNA damage response and, more importantly, facilitate the maintenance of the terminal DNA sequence ...
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(2012-02-14)Telomerase is a highly regulated ribonucleoprotein complex that stabilizes eukaryotic genomes by replenishing telomeric repeats on chromosome ends. Defects in telomerase RNP components involving the catalytic subunit TERT ...
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(2012-10-19)Telomeres form a nucleoprotein cap at the end of eukaryotic chromosomes. The telomere protein constituents repress the DNA damage response (DDR) and facilitate maintenance of terminal sequences by a specialized ribonucleoprotein ...
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(2014-11-06)Telomeres are the physical ends of eukaryotic chromosomes. Because chromosome ends resemble double–strand breaks, telomere binding proteins mask telomeres from DNA damage response machinery. Consequently, telomere protection ...
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(2013-09-11)The ends of chormosomes are capped by telomeres, which distinguish the termini from damaged DNA. Paradoxically, DNA repair proteins are also required for telomere maintenance. How DNA repair pathways are regulated to ...