Browsing by Subject "NR4A1"
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Diindolylmethane Analogs as Novel NR4A1 Antagonists and as a Novel Class of Anticancer Agents and Sp Transcription Factors as Nononcogene Addiction Genes That Are Targets of ROS Inducing Agents
(2016-12-13)The orphan nuclear receptor 4A1 (NR4A1) and specificity protein (Sp) transcription factors (TFs) are both overexpressed in the majority of solid tumors. Our laboratory has researched the molecular mechanisms of a novel ... -
Mechanism of Action of Sulindac and Diindolylmethane Analogs as Anticancer Agents
(2014-05-07)Cancer accounts for one in eight deaths worldwide and one in four deaths in the United States. Chemotherapy is the most common treatment option for cancer; however, many chemotherapeutic drugs have toxic side effects. Our ... -
NR4A1 Antagonists Target the Oncogenic PAX3-FOXO1A Gene and Induce Interleukin -24 in Rhabdomyosarcoma (RMS)
(2017-08-03)Rhabdomyosarcoma (RMS) is a pediatric cancer for which common therapeutics include cytotoxic chemotherapeutics that result in adverse health outcomes later in adulthood. Previous studies have found NR4A1 expression contributes ...