Browsing by Subject "Epigenetics"
Now showing items 1-10 of 10
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(2016-12-06)Methylation of the carbon 5 position of cytosine is a common epigenetic mark in vertebrates, and has been associated with male infertility. Methylation can be affected by environmental changes in utero and our long-term ...
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(2012-10-19)Accumulated genetic and epigenetic abnormalities contribute to the development of colon cancer. We have shown that a combination of fish oil (containing decosahexaenoic acid, DHA, 22:6 n-3) and pectin (fermented to butyrate ...
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(2021-07-06)The human cell-free DNA (cfDNA) methylation profile in liquid biopsy has been utilized to diagnose early-stage disease and estimate therapy response. However, typical clinical procedures are capable of purifying only very ...
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(2021-09-01)Epigenetic alterations, such as changes in DNA methylation, histones/chromatin structure, nucleosome positioning, and expression of non-coding RNAs, are recognized among key characteristics of carcinogens; they may occur ...
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(2015-12-02)Observations from a number of independent laboratories indicate that ethanol has the capacity to act as a powerful epigenetic disruptor and potentially derail the process of cellular differentiation. The aim of this ...
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(Texas A&M University, 2005-02-17)Bovine preimplantation embryos derived from nuclear transfer experiments exhibit a global state of genomic hypermethylation that likely account for the large number of developmental abnormalities observed to date. The ...
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This project investigates the reason why the placentas of mice sired by males exposed to alcohol prior to conception are larger and less efficient than placentas of control mice. This research question is important because ...
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(2017-04-28)Telomeres are specialized nucleoprotein caps at the end of linear chromosomes, critical for genome stability. A major function of telomeres is to distinguish chromosome ends from ends of double strand breaks. A second ...
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(2019-11-15)Alcohol is a notorious teratogen and a major driver of both mental and physical defects. Recently, alcohol has been discovered to exert intergenerational effects on offspring development. While maternal exposure to alcohol ...
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(2021-07-20)Post-traumatic epilepsy (PTE) is a life-long seizure disorder that can arise from traumatic brain injury (TBI). In addition to the rapid inflammatory response and lesion-site necrosis, TBI induces immediate and long-term ...