Browsing by Subject "Drug discovery"
Now showing items 1-4 of 4
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(2021-12-10)This dissertation presents an in-silico molecular-dynamic-simulation-based drug discovery tool and its utility to find inhibitors for pathogenic microorganisms. Specifically, the applicability of the tool has been demonstrated ...
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(2022-11-23)Aggregation of pyrrolysyl-tRNA synthetase (PylRS) has proven problematic for expression of non-canonical amino acids (ncAAs) in proteins. C. M. alvus PylRS (CMaPylRS) is a highly soluble PylRS with a shorter N-terminal ...
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(2020-03-23)Structural information on protein-ligand complexes is of key interest in pharmaceutical research, as it provides rational guidance for optimizing ligand affinity and selectivity. An efficient tool for probing protein-ligand ...
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(2013-12-09)Mycobacterium tuberculosis (M. tuberculosis) contains a wide array of genes responsible for the synthesis and secretion of a variety of bioactive lipids. The genes represent attractive drug-targets due to their involvement ...