Browsing by Subject "Drug Discovery"
Now showing items 1-5 of 5
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(2021-12-09)Tuberculosis, the disease caused by the mycobacterial pathogen Mycobacterium tuberculosis, has been, prior to the COVID-19 pandemic, the world’s deadliest infectious disease. The illness has been afflicting humans for ...
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(2016-12-14)Current therapies for treatment of mycobacterial infections are adequate when diagnosis and pathology is well defined. Yet more evidence is beginning to accumulate for the multitude of reasons behind drug insensitive ...
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Antibiotic discovery has stagnated. To avoid catastrophe, it must speed up. One of the most heavily used methods of drug discovery is high-throughput screening, yet in the 40 years of use of high-throughput screening, zero ...
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(2016-02-12)As the world population battles drug-resistant tuberculosis (TB), there is an urgent need for novel anti-tubercular drugs. This dissertation documents the studies of glyoxylate shunt enzymes, isocitrate lyase (ICL) and ...
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(2013-11-07)Natural products are a rich source of compounds with interesting structures and biological activities. Three bioactive natural products, iriomoteolide-1a, alotaketal A, and an unnamed quinone methide diterpenoid, attracted ...