Browsing by Subject "CRISPR/Cas9"
Now showing items 1-9 of 9
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(2015-11-18)MicroRNAs are short regulatory RNAs that primarily operate at the posttranscriptional level, acting as part of the RISC complex to destabilize mRNA prior to, or during, translation. MicroRNAs are subject to several levels ...
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(2021-04-07)Since the dawn of life on Earth, organisms have had to overcome tremendous challenges in securing food, territory, and mates in order to survive daily and seasonal environmental fluctuations imposed by the rotation of the ...
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(2018-05-08)CRISPR-Cas9 has been employed as a genome editing tool in a wide range of cells of different organisms. One of the biggest challenges it faces is to maintain the efficiency of the gene regulation. To address this challenge, ...
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(2022-01-11)The CRISPR/Cas9 genome editing system has been tested, validated, and applied in plants since its introduction in 2012. For plant breeders, the CRISPR system’s ability to provide targeted genetic modifications is an ...
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(2019-04-29)Sox2 and Sox3 are SoxB1 transcription factors that act redundantly in the neural ectoderm, but also are uniquely required in other systems. To address functions of sox2 and sox3 in otic and epibranchial development, we ...
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(2023-05-01)Bacterial blight of cotton (BBC) is a destructive foliar disease caused by the pathogen Xanthomonas citri pv. malvacearum (Xcm). The primary virulence strategy of Xanthomonas spp. involves the use of transcription ...
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(2022-06-02)Griscelli Syndrome type 1 (GS1) is an ultra-rare, autosomal recessive human disease that affects vesicle and membrane trafficking caused by a mutation in the Myosin-Va gene. Myosin-Va is an unconventional motor protein ...
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(2018-06-28)Plant viruses can be engineered and utilized as transient tools for foreign gene overexpression studies and large-scale production of high value proteins. Tobacco mosaic virus (TMV) has been widely used for these purposes. ...
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(2018-07-27)The CRISPR/Cas9 site-specific nuclease from a prokaryotic viral defense mechanism has been adapted into a gene editing tool for molecular biologists. Consisting of two deliverable parts, a Cas9 nuclease and sequence specific ...