Browsing by Author "Wooley, Karen"
Now showing items 1-17 of 17
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Kim, Jihyun (2020-07-17)Structural changes occurring during the folding and unfolding of proteins are not directly accessible with nuclear magnetic resonance (NMR) spectroscopy due to a slower timescale of detection compared to that of the folding ...
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Kalin, Alexander (2020-02-10)Conjugated ladder polymers consist of π-conjugated, fused-ring repeating units, linked together by multiple strands of bonds. Such structural feature rigidifies the backbone and imparts unique chemical, optical, and ...
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Thivierge, Cliferson (2012-07-16)The challenges in modern biological imaging applications are two-fold: (i) to develop better methods of imaging, and (ii) develop dyes that are suitable for these methods. This dissertation deals with the design and ...
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The Development of Werner-type Cobalt Complexes in Enantioselective Hydrogen Bond Mediated Catalysis Lewis, Kyle (2013-12-03)Chiral-at-metal Werner complexes of the type (Λ/∆)-[Co(1,2-diamine)_(3)]^(3+) 3X^(–)have long been a cornerstone of coordination chemistry. However, despite being inexpensive and readily available in enantiopure ...
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Sanders, Jonathan Edward (2015-08-11)The application of engineered nanomaterials has improved many traditional groundwater remediation technologies; however, the development of novel nano-scale remediation technologies remains limited. magnetic shell crosslinked ...
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Park, Jihye (2016-06-17)Metal–organic frameworks (MOFs) are newly emerging inorganic–organic hybrid porous materials with diverse crystalline structures, high surface areas, and tunable pores. This dissertation primarily focuses on design and ...
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Patrick, John W (2017-01-05)One of the most rapidly advancing subjects studied by analytical chemistry, biology, and biophysics is the analysis of membrane associated peptides and proteins from a native lipid environment. Mass spectrometry (MS) has ...
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Larner, Craig (2012-10-19)With the severity of cardiovascular disease (CVD) and the related mortality rate to this disease, new methods are necessary for risk assessment and treatment prior to the onset of the disease. The current paradigm in CVD ...
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Yang, Xinyu (2019-05-30)Metal-organic frameworks (MOFs) and porous polymer networks (PPNs) are emerging porous materials that exhibit high crystallinity, large surface areas, and excellent tunability. With these features, MOFs and PPNs demonstrate ...
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Wagers, Patrick; Tiemann, Kristin; Shelton, Kerri; Kofron, William; Panzner, Matthew; Wooley, Karen; Youngs, Wiley; Hunstad, David (Antimicrobial Agents and Chemotherapy, 2015)
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Evans, Jordan Andrew (2013-05-03)The objectives of this thesis are to produce radioactive antibody-conjugated gold nanoparticles to improve the efficacy of targeted radionuclide therapy for the treatment of cancer, and to demonstrate that this product can ...
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Brock, Dakota James (2019-07-23)The effective delivery of hydrophilic, bioactive molecules, such as enzymes and nucleic acids, to the cytosol of cells has proven to be a multibillion-dollar problem for cell biologists and the pharmaceutical industry. In ...
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Wang, Ting-Yi (2016-08-03)Cell-penetrating peptides (CPPs) enter cells primarily through escaping from endosomal compartments or directly translocating across the plasma membrane. Due to their capability of permeating into the cytosolic space of ...
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Kim, Yaewon (2018-11-21)NMR spectroscopy is one of the front-line techniques in drug screening for binding identification and affinity determination. A critical issue that limits the scope of NMR in screening applications is low detection ...
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Wooley, Karen; Zou, Jiong; El Sabahy, Mahmoud; Zhang, Shiyi; Zhang, Fuwu (United States. Patent and Trademark Office; Texas A&M University. Libraries, 2017-01-17)The present disclosure generally relates to polymer-drug systems, and more particularly to nanoscopic particles comprising amphiphilic block copolymers conjugated, physically encapsulated, or otherwise combined with ...
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Hernandez, Joshua Joel (2017-06-29)Scale formation is an ongoing production issue in the oil and gas industry where inorganic salts can form deposits downhole or in production facilities. These deposits can severely hinder production and lead to significant ...
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Kaiser, Thomas Maxwell (2013-11-11)Pharmaceutical R&D is currently undergoing a productivity crisis. Also, the loss of activity of established medicines continues to reduce the pool of agents capable of treating infectious diseases. Small molecule synthesis ...