Browsing by Author "Threadgill, David"
Now showing items 1-20 of 23
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Vandehoef, Crissie Louise (2022-01-12)Dietary nutrients shape complex interactions between hosts and their commensal gut bacteria. The composition of commensal bacterial species can thus shift in response to changes in host dietary nutrient availability, ...
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Blanchette, Alexander Daniel (2021-08-25)Cardiovascular disease is a major cause of morbidity and mortality worldwide, but there is little knowledge on the potential cardiovascular effects for most environmental chemicals. Causal links to cardiovascular disease ...
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Popp, Julia L (2021-07-26)Contemporary approaches for developing new interventions and for pre-clinical risk evaluation include assessments for cardiovascular structure and function, frequently performed in a variety of animal and in vitro models, ...
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Scoggin, Kristin (2021-12-02)Salmonella Typhimurium (STm) usually cause self-limiting gastroenteritis. In some individuals, these bacteria can spread systemically and cause disseminated disease. Rising incidence of antibiotic resistance in STm is a ...
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Stubbendieck, Reed Michael (2017-05-02)Throughout history, especially beginning in the mid-twentieth century, humans have adapted numerous specialized metabolites produced by microbes as therapeutics. Since their inception, antibiotics have been a powerful tool ...
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Moore, Lora A (2015-11-10)Although interest in the gut microbiome is at the forefront of research in recent years, there is still much to discover about its ever-changing nature and its importance to our health. This study examined the effects of ...
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Seniutkin, Oleksii (2017-04-13)Liver fibrosis results from chronic damage and excessive regeneration with redundant accumulation of extracellular matrix proteins, including collagen. Liver fibrosis may be caused by infectious, environmental, and autoimmune ...
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Bansal, Mayur (2020-04-20)Beta-catenin (CTNNB1) is a key downstream effector of the WNT signaling pathway, a pathway involved in embryonic development and tumorigenesis. To further study the role of CTNNB1 in gut tumorigenesis, mice homozygous for ...
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Goodman, Samantha Joyce (2021-09-01)Epigenetic alterations, such as changes in DNA methylation, histones/chromatin structure, nucleosome positioning, and expression of non-coding RNAs, are recognized among key characteristics of carcinogens; they may occur ...
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Hammer, Staci Elizabeth (2023-11-30)Folate, or vitamin B9, is a key component in one-carbon (1C) metabolism that supports precursor molecules required for growth and development. Folate is found in some natural foods, and its synthetic form is called folic ...
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Zhang, Linying (2022-06-07)As a prototypic ciliated protozoan, Tetrahymena thermophila harbors two functionally and physically distinct nuclei within a shared cytoplasm. During the vegetative phase of the life cycle, the S phases of the diploid ...
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Nagarajan, Aravindh (2023-10-03)The Collaborative Cross (CC) mouse population is an ideal tool for systems genetics. We have used this tool to examine several aspects of host-pathogen biology: (1) Defining diversity in disease outcome to S. aureus ...
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Perez Gomez, Aracely Anahi (2023-04-19)Infection by a single virus or exposure to an immunotoxicant can evoke diverse immune responses leading to neurological disorders dependent on the host’s genetic background. Predisposing risk factors for neurological ...
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Mantilla Rojas, Carolina (2019-11-13)Colorectal cancer (CRC) ranks among the third most common human malignant diseases and is one of the leading causes of cancer-related deaths globally. The epidermal growth factor receptor (EGFR) is recognized as an important ...
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Si, Meghan LeColorectal cancer (CRC) is the second leading cause of cancer-related deaths in the United States and with the incidence of early-onset CRC on the rise, the CRC burden is rapidly shifting towards a younger population of ...
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Pflug, Kathryn M (2021-11-08)NF-κB-inducing kinase (NIK), the essential upstream kinase which regulates activation of the noncanonical NF-κB pathway, has important roles in regulating immunity and inflammation. In addition, NIK is vital for maintaining ...
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Jung, Jiung (2018-05-03)NF-κB inducing kinase (NIK, also known as MAP3K14) is a serine/threonine protein-kinase that is crucial for activation of the non-canonical NF-κB signaling pathway. Although NIK has been shown to promote tumorigenesis in ...
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Kelly, Scott; Zhao, Liyang; Jung, Kuo-Chen; Hua, Kunjie; Threadgill, David; Kim, Yunjung; Fernando Pardo Manuel de Villena; Pomp, Daniel (Scientific Reports, 2017)
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Perry, Amie Lynn (2019-02-20)Development of a rodent model for renal cancer and disease development due to toxicant exposure is complicated by differences in renal handling of toxicants between rodents and humans as well as the tendency of rodents to ...
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Williamson, Madison Michaela (2022-10-31)Mitophagy has become an increasingly important topic for addressing pathologies of neurodegenerative disease. Yet there is still much to be understood about the key players that regulate mitophagy as well as its involvement ...