Browsing by Author "Straight, Paul"
Now showing items 1-20 of 36
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Francis, Michael (2017-05-10)Infections caused by Clostridium difficile have increased steadily over the past several years. While studies on C. difficile virulence and physiology have been hindered, in the past, by lack of genetic approaches and ...
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Stubbendieck, Reed; Vargas-Bautista, Carol; Straight, Paul (Frontiers in Microbiology, 2016)
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Lamb, Austin Casey (2023-01-06)Bioenergy sorghum has a high biomass yield potential, is drought resilient, has good nitrogen use efficiency, and has a root system that contributes to the accumulation of soil organic carbon. In this dissertation, field ...
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Thompson, Natalie (2012-10-19)Karenia brevis is the major harmful algal bloom-forming species in the Gulf of Mexico, and produces neurotoxins, known as brevetoxins, that cause large fish kills, neurotoxic shellfish poisoning, and human respiratory ...
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Truong, Dat Phuoc (2020-03-06)Catalytic promiscuity is the coincidental ability for an enzyme to catalyze nonbiological reactions in the same active site as the native biological reaction. Several lines of evidence show that catalytic promiscuity plays ...
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McFarlin, Rae (2013-05-02)The development of methods for site-selective derivatization of natural products to enable simultaneous arming and structure activity relationship (SAR) studies has shown great potential for the synthesis of pharmaceutical ...
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Jani, Sneha Jagdish (2017-05-08)Bacteria navigate within their environment in response to gradients of several environmental cues, including nutrients, toxins, pH, temperature and oxygen. Recent studies demonstrate that Escherichia coli also senses ...
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Stubbendieck, Reed Michael (2017-05-02)Throughout history, especially beginning in the mid-twentieth century, humans have adapted numerous specialized metabolites produced by microbes as therapeutics. Since their inception, antibiotics have been a powerful tool ...
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Goble, Alissa M (2013-04-24)Improved sequencing technologies have created an explosion of sequence information that is analyzed and proteins are annotated automatically. Annotations are made based on similarity scores to previously annotated sequences, ...
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Mosior, John W (2021-04-07)Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is the leading cause of infectious death worldwide. In particular, the rise in incidence of drug resistant Mtb strains has made it imperative to ...
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Ragavan, Mukundan (2014-06-27)Nuclear Magnetic Resonance (NMR) spectroscopy provides remarkable site resolution, but often requires signal averaging because of low sensitivity. Dissolution dynamic nuclear polarization (DNP), which offers large signal ...
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Xiao, Chunying (2015-10-02)The effects of charge states, charge sites and side chain interactions on conformational preferences of gas phase peptide ions are examined by ion mobility-mass spectrometry (IM-MS) and molecular dynamics (MD) simulations. ...
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Ababneh, Qutaiba O (2015-08-10)The nucleotide second messengers pppGpp and ppGpp ((p)ppGpp) are responsible for the global down-regulation of transcription, translation, DNA replication, and growth rate during stringent response. More recent studies ...
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Berry, Joel Dallas (2011-08-08)The purpose of the work described in this dissertation is to better understand the role of Rz and Rz1 function with respect to phage lysis. We determined using both a genetic and biochemical approach that the Rz protein ...
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Hitchcock, Daniel Stephen (2014-02-24)High throughput sequencing technology and availability of this information has changed the way enzyme families can be studied. Sequence information from large public databases such as GenBank and UniProtKB can easily ...
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Walker, Thomas E (2022-12-08)In recent years, native mass spectrometry (nMS) has continued to grow in popularity and recognition as an excellent structural biology tool. The implementation of orthogonal methods to nMS, such as liquid chromatography ...
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Zhang, Chengxi (2020-07-30)In natural habitats, microorganisms synthesize specialized metabolites and enzymes that mediate chemical interactions between organisms. Those natural products have various biological activities, acting as signaling ...
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Liu, Yongjin (2020-06-18)Nanomechanical responses of brittle materials, such as glass and ceramics, are important for various industrial applications. Understanding their deformation and failure mechanisms would offer new knowledge and help design ...
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Hughes, Ryan C (2016-12-14)Current therapies for treatment of mycobacterial infections are adequate when diagnosis and pathology is well defined. Yet more evidence is beginning to accumulate for the multitude of reasons behind drug insensitive ...
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Xiang, Wang (2018-08-06)Macrophages are a heterogeneous population of cells and, include classically activated macrophages (M1) and alternatively activated macrophages (M2). Macrophages can change from M1 to M2 and vice versa in response to ...