Browsing by Author "Sachs, Matthew"
Now showing items 1-20 of 23
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Francis, Michael (2017-05-10)Infections caused by Clostridium difficile have increased steadily over the past several years. While studies on C. difficile virulence and physiology have been hindered, in the past, by lack of genetic approaches and ...
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To, Kam Ho (2013-11-06)Bacteriophages infect and kill bacterial cells. During the infection cycle, a phage attaches to the host cell surface, then ejects its DNA into the cytoplasm, where its progenies are subsequently assembled. The final ...
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Ravichandran, Akshaya (2016-12-08)Fungal infections caused by opportunistic pathogens tend to be particularly severe and systemic in the case of immunocompromised patients. The current treatment options fall under classes such as azoles, polyenes, echinocandins ...
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Xu, Hengyi (2015-05-13)In eukaryotes the ends of chromosomes are constituted by nucleoprotein complexes termed telomeres. Telomeres represses a DNA damage response and, more importantly, facilitate the maintenance of the terminal DNA sequence ...
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Jayant Kumar Ojha, Nikita (2016-05-06)Circadian regulation of Mitogen Activated Protein Kinase (MAPK) pathways provides a priming mechanism to allow organisms to anticipate daily environmental stresses such as heat, light, desiccation and osmotic stress. In ...
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Caster, Stephen; Castillo, Kathrina; Sachs, Matthew; Bell-Pedersen, Deborah (Proceedings of the National Academy of Sciences of the United States of America, 2016)
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Ding, Zhaolan (2021-04-22)At least half of proteins cycling in abundance under control of the circadian clock in eukaryotic cells are synthesized from non-cycling mRNAs. These data suggested that the clock controls posttranscriptional events, ...
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Karki, Shanta (2019-10-07)Up to half of the eukaryotic genome is controlled by the endogenous circadian clock at the level of rhythmic transcript abundance. The clock also controls post-transcriptional events, including clock regulation of the ...
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Harford, Tamika Shonna (2022-11-17)Daily circadian rhythms are under the control of an endogenous timekeeper, the circadian clock, which confers an adaptive advantage to organisms by providing the ability to prepare for daily environmental changes and to ...
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Taylor, Cody A (2023-05-16)The endogenous circadian clock controls daily rhythms in gene expression, metabolism, and behavior [1-3]. Circadian clock control of specific metabolites has been studied in different organisms; however, little is known ...
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Taylor, Cody A (2023-05-16)The endogenous circadian clock controls daily rhythms in gene expression, metabolism, and behavior [1-3]. Circadian clock control of specific metabolites has been studied in different organisms; however, little is known ...
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Taylor, Cody A (2023-05-16)The endogenous circadian clock controls daily rhythms in gene expression, metabolism, and behavior [1-3]. Circadian clock control of specific metabolites has been studied in different organisms; however, little is known ...
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Stubbendieck, Reed Michael (2017-05-02)Throughout history, especially beginning in the mid-twentieth century, humans have adapted numerous specialized metabolites produced by microbes as therapeutics. Since their inception, antibiotics have been a powerful tool ...
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Sun, Di (2021-01-11)Posttranscriptional gene silencing (PTGS) involves two kinds of small non-coding regulatory RNAs, miRNA and small interfering RNA (siRNA) that regulate gene expression in diverse biological processes in eukaryotic organisms. ...
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Gomez, Jana Marie (2021-04-24)The circadian clock is an intrinsic time-keeping mechanism that is conserved between many species, ranging from cyanobacteria to mammals. Due to circadian clock conservation between organisms, understanding how the clock ...
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Ceballos, Mariana (2012-10-19)Following a head concussion the intracranial pressure increases due to the impact, which cannot be adequately relieved because of the stiffness of the skull. Popular strategies aimed at decompressing the head consist in ...
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Nsa, Imade Yolanda (2013-08-13)Circadian clocks are composed of molecular oscillators and are found in most eukaryotes and some prokaryotes. The fungus Neurospora crassa is a leading model for studying the clock. In N. crassa, the well-described FRQ/WCC ...
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Yang, Kailu (2018-04-17)Gene expression in the human pathogen, Mycobacterium tuberculosis (M. tuberculosis), may possess species-specific structural features that can be targeted by drugs. Previous studies have identified, for example, several ...
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Caster, Stephen Z (2016-08-01)Stress response pathways function to allow cells to adapt to changes in the environment. In Neurospora crassa, acute osmotic stress activates the conserved p38-like osmosensing mitogen-activated protein kinase (OS MAPK) ...
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Hoose, Scott Allen (2012-10-19)Cell replication and division are central to the proliferation of life, and have implications for normal growth and development as well as disease state. Assembly of a complete picture of the systems which control this ...