Browsing by Author "Sacchettini, James C."
Now showing items 1-20 of 51
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Mire, Joseph Andrew (2013-07-24)β-lactamase enzymes catalyze the irreversible hydrolysis of the four-membered cyclic amide ring characteristic of β-lactam antibiotics rendering them inactive and useless against pathogenic bacteria. Understanding structure ...
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Ioerger, Thomas R.; Sacchettini, James C. (Acta Crystallographica. Section D - Biological Crystallography, 2002)
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DeJesus, Michael A. (2012-07-16)Determining which genes are essential for growth of a bacterial organism is an important question to answer as it is useful for the discovery of drugs that inhibit critical biological functions of a pathogen. To evaluate ...
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Reyes Caballero, Hermes (2012-10-19)NmtR and AdcR belong to two structural and functional classes of transcriptional metalloregulators. The present study shows that AdcR is a novel Zn(II) dependent repressor and the first ever metalloregulator of the MarR ...
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Reddy, Manchi C. M.; Sacchettini, James C.; Zhou, Nian E.; McCutchen, Billy F. (United States. Patent and Trademark Office; Texas A&M University. Libraries, 2021-08-10)Compositions and methods for inhibiting and/or sensitizing or re-sensitizing a parasite to an antiparasitic drug are provided. The compositions can comprise a an arylphenoxypropionate derivative, an aryloxyphenoxyacetate ...
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Reddy, Manchi C. M.; Sacchettini, James C.; Zhou, Nian E.; McClutchen, Billy F. (United States. Patent and Trademark Office; Texas A&M University. Libraries, 2020-01-28)Compositions and methods for inhibiting and/or sensitizing or re-sensitizing a parasite to an antiparasitic drug are provided. The compositions can comprise a an arylphenoxypropionate derivative, an aryloxyphenoxyacetate ...
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Reddy, Manchi C. M.; Sacchettini, James C.; Zhou, Nian E.; Mccutchen, Billy F. (United States. Patent and Trademark Office; Texas A&M University. Libraries, 2019-05-28)A composition comprising a drug selected from the group consisting of an arylphenoxypropionate derivative, an aryloxyphenoxyacetate derivative, an aryloxyphenylacetate derivative, a substituted quinol, or a salt, hydrate, ...
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Reddy, Manchi C. M.; Sacchettini, James C.; Zhou, Nian E.; McCutchen, Billy F. (United States. Patent and Trademark Office; Texas A&M University. Libraries, 2019-05-28)A composition comprising a drug selected from the group consisting of an arylphenoxypropionate derivative, an aryloxyphenoxyacetate derivative, an aryloxyphenylacetate derivative, a substituted quinol, or a salt, hydrate, ...
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Shi, Xiaoshan; Festa, Richard A.; Ioerger, Thomas R.; Butler-Wu, Susan; Sacchettini, James C.; Darwin, K. Heran; Samanovic, Marie I. (MBio, 2014)
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Crystallization and mutational studies of carbon monoxide dehydrogenase from moorella thermoacetica Kim, Eun Jin (Texas A&M University, 2004-09-30)Carbon Monoxide Dehydrogenase (CODH), also known as Acetyl-CoA synthase (ACS), is one of seven known Ni containing enzymes. CODH/ACS is a bifunctional enzyme which oxidizes CO to CO2 reversibly and synthesizes acetyl-CoA. ...
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Holton, Thomas; Ioerger, Thomas R.; Christopher, Jon A.; Sacchettini, James C. (Acta Crystallographica. Section D - Biological Crystallography, 2000)
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Gopal, Kreshna (2009-06-02)Data preprocessing is critical for machine learning, data mining, and pattern recognition. In particular, selecting relevant and non-redundant features in highdimensional data is important to efficiently construct models ...
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Berry, Joel Dallas (2011-08-08)The purpose of the work described in this dissertation is to better understand the role of Rz and Rz1 function with respect to phage lysis. We determined using both a genetic and biochemical approach that the Rz protein ...
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Thorstad, Melissa (2013-05-23)In 1996, scientists discovered a connection between the gene for the human protein frataxin (FXN) and the neurodegenerative disease Friedreich’s ataxia (FRDA). Decreased FXN levels result in a variety of aberrant phenotypes ...
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Loesch, Kimberly; Galaviz, Stacy; Hamoui, Zaher; Clanton, Ryan; Akabani, Gamal; Deveau, Michael; DeJesus, Michael; Ioerger, Thomas; Sacchettini, James C.; Wallis, Deeann; Fraidenraich, Diego (PloS One, 2015)
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Ioerger, Thomas R.; Koo, Sunwoo; No, Eun-Gyu; Chen, Xiaohua; Larsen, Michelle H.; Jacobs, William R.; Pillay, Manormoney; Sturm, A. Willem; Sacchettini, James C.; Marais, Ben (PloS One, 2009)
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Zhang, Yanjia J.; Ioerger, Thomas R.; Huttenhower, Curtis; Long, Jarukit E.; Sassetti, Christopher M.; Sacchettini, James C.; Rubin, Eric J.; Behr, Marcel A. (PLoS Pathogens, 2012)
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Bageshwar, Umesh K.; VerPlank, Lynn; Baker, Dwight; Dong, Wen; Hamsanathan, Shruthi; Whitaker, Neal; Sacchettini, James C.; Musser, Siegfried M.; Cascales, Eric (PloS One, 2016)
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Ngubane, Nqobile A. C.; Gresh, Lionel; Ioerger, Thomas R.; Sacchettini, James C.; Zhang, Yanjia J.; Rubin, Eric J.; Pym, Alexander; Khati, Makobetsa; Willson, Richard C. (PloS One, 2013)
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Romo, Tod D.; Sacchettini, James C.; Ioerger, Thomas R. (Acta Crystallographica. Section D - Biological Crystallography, 2006)