Browsing by Author "Sacchettini, James"
Now showing items 1-20 of 47
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Fox, Nicholas G (2014-06-02)Iron sulfur (Fe-S) clusters are essential cofactors that function in electron transport, catalyzing substrate turnover, environmental sensing, and initiating radical chemistry. Elaborate multi-component systems have evolved ...
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Truong, Dat Phuoc (2020-03-06)Catalytic promiscuity is the coincidental ability for an enzyme to catalyze nonbiological reactions in the same active site as the native biological reaction. Several lines of evidence show that catalytic promiscuity plays ...
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Geng, Mengxin (2019-02-11)Lantibiotics are a class of lanthionine-containing, ribosomally synthesized and post-translationally modified peptides (RiPPs) with antimicrobial activities, and are among the most promising candidates of alternative ...
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Wu, Fei (2009-05-15)Estrogen receptor α (ERα) is a ligand activated transcription factor. Many widely used synthetic compounds and natural chemicals can activate ERα. The compounds investigated in this study include 17β-estradiol (E2), ...
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Vargas Bautista, Carol M (2014-08-27)The pks genes are the largest antibiotic- encoding gene cluster in Bacillus subtilis and encode the Pks enzymatic complex that produces bacillaene. Bacillaene plays important roles in the fitness of B. subtilis during ...
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Sacchettini, James; Zhou, Niam; Baker, Dwight; Maxwell, Steven A.; Wallis, Deeann (United States. Patent and Trademark Office; Texas A&M University. Libraries, 2015-09-15)The disclosure provides rifamycin and rifamycin derivative compositions, including rifabutin and rifabutin derivative compositions able to cause drug-sensitization in a cancer cell or inhibition of a cancer cell. The ...
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Sacchettini, James; Zhou, Niam; Baker, Dwight; Maxwell, Steven A.; Wallis, Deeann (United States. Patent and Trademark Office; Texas A&M University. Libraries, 2018-01-16)The disclosure provides rifamycin and rifamycin derivative compositions, including rifabutin and rifabutin derivative compositions able to cause drug-sensitization in a cancer cell or inhibition of a cancer cell. The ...
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Sacchettini, James; Zhou, Niam; Baker, Dwight; Maxwell, Steven A.; Wallis, Deeann (United States. Patent and Trademark Office; Texas A&M University. Libraries, 2017-01-10)The disclosure provides rifamycin and rifamycin derivative compositions, including rifabutin and rifabutin derivative compositions able to cause drug-sensitization in a cancer cell or inhibition of a cancer cell. The ...
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Harshbarger, Wayne (2012-10-19)Thymidylate synthase (TS), encoded by the ThyA gene, is essential for the growth and survival of Mycobacterium tuberculosis and therefore is a potential drug target. Thymidylate synthase binds both a substrate, ...
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Stanley, Sarah; Kawate, Tomohiko; Iwase, Noriaki; Shimizu, Motohisa; Clatworthy, Anne; Kazyanskaya, Edward; Sacchettini, James; Ioerger, Thomas; Siddiqi, Noman; Minami, Shoko; Aquadro, John; Sarah Schmidt Grant; Rubin, Eric; Hung, Deborah (Proceedings of the National Academy of Sciences of the United States of America, 2013)
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Mosior, John W (2021-04-07)Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is the leading cause of infectious death worldwide. In particular, the rise in incidence of drug resistant Mtb strains has made it imperative to ...
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Andrés Palencia; Li, Xianfeng; Bu, Wei; Choi, Wai; Ding, Charles; Easom, Eric; Feng, Lisa; Hernandez, Vincent; Houston, Paul; Liu, Liang; Meewan, Maliwan; Mohan, Manisha; Rock, Fernando; Sexton, Holly; Zhang, Suoming; Zhou, Yasheen; Wan, Baojie; Wang, Yuehong; Franzblau, Scott; Woolhiser, Lisa; Gruppo, Veronica; Lenaerts, Anne; Theresa O'Malley; Parish, Tanya; Cooper, Christopher; M. Gerard Waters; Ma, Zhenkun; Ioerger, Thomas; Sacchettini, James; Joaquín Rullas; Iñigo Angulo-Barturen; Esther Pérez-Herrán; Mendoza, Alfonso; Barros, David; Cusack, Stephen; Plattner, Jacob; M. R. K. Alley (Antimicrobial Agents and Chemotherapy, 2016)
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Ragavan, Mukundan (2014-06-27)Nuclear Magnetic Resonance (NMR) spectroscopy provides remarkable site resolution, but often requires signal averaging because of low sensitivity. Dissolution dynamic nuclear polarization (DNP), which offers large signal ...
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Pai Karkala, Reetal (2010-07-14)Recent improvements in structural genomics efforts have greatly increased the number of hypothetical proteins in the Protein Data Bank. Several computational methodologies have been developed to determine the function of ...
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Zhang, Chengxi (2020-07-30)In natural habitats, microorganisms synthesize specialized metabolites and enzymes that mediate chemical interactions between organisms. Those natural products have various biological activities, acting as signaling ...
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Ioerger, Thomas; Theresa O’Malley; Liao, Reiling; Guinn, Kristine; Hickey, Mark; Mohaideen, Nilofar; Murphy, Kenan; Boshoff, Helena; Mizrahi, Valerie; Rubin, Eric; Sassetti, Christopher; Barry, Clifton; III; Sherman, David; Parish, Tanya; Sacchettini, James (PloS One, 2013)
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Hong, Wei; Wang, Yu; Chang, Zhe; Yang, Yanhui; Pu, Jing; Sun, Tao; Kaur, Sargit; Sacchettini, James; Jung, Hunmin; Wee Lin Wong; Lee Fah Yap; Yun Fong Ngeow; Paterson, Ian; Wang, Hao (Scientific Reports, 2015)
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Leon Quinonez, StephanieFrontline tuberculosis drugs, i.e. Isoniazid, have become inefficient as strains of Mycobacterium Tuberculosis have become multi-drug resistant, creating an urgent need for novel antitubercular drugs. The key to the bacterium ...
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Hughes, Ryan C (2016-12-14)Current therapies for treatment of mycobacterial infections are adequate when diagnosis and pathology is well defined. Yet more evidence is beginning to accumulate for the multitude of reasons behind drug insensitive ...
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Wood, Jeremy Lee (2019-04-19)Combating the persistent threat and low therapeutic success of treating multidrug-resistant Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis, demands a worldwide effort to discover and develop new ...