Browsing by Author "Li, Jianrong"
Now showing items 1-20 of 23
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Turtle, Joel Dylan (2018-01-23)Over 90% of spinal cord injuries are caused by traumatic accidents and are often associated with secondary tissue damage that can provide a source of continued pain input. Previous work has shown that nociceptive stimulation ...
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Steelman, Andrew J; Li, Jianrong (Journal of Neuroinflammation, 2014)
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Caspase blockade induces RIP3-mediated programmed necrosis in Toll-like receptor-activated microglia Kim, S J; Li, Jianrong (Cell Death & Disease, 2013)
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Woller, Sarah Ann (2013-07-16)Approximately two-thirds of patients will experience pain following spinal cord injury (SCI). This pain can arise as an immediate consequence of SCI, or can develop over time into chronic, neuropathic pain. Individuals ...
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Ji, Pengfei (2022-01-03)Sepsis is a threat to human healthy and caused by infection with a systemic inflammatory response. Sepsis ranges from endotoxemia to more severe and long-term effects. Moreover, the low blood pressure and inflammation ...
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Zhao, Chuntao; Deng, Yaqi; Liu, Lei; Yu, Kun; Zhang, Liguo; Wang, Haibo; He, Xuelian; Wang, Jincheng; Lu, Changqing; Wu, Laiman; Weng, Qinjie; Mao, Meng; Li, Jianrong; Johan H van Es; Xin, Mei; Parry, Lee; Goldman, Steven; Clevers, Hans; Q. Richard Lu (Nature Communications, 2016)
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Effects of Morphine on Activated Microglia and Macrophages in a Rodent Model of Spinal Cord Injury Terminel, Mabel N (2020-07-10)Opioids are among the most effective and commonly prescribed analgesics for the treatment of acute pain after spinal cord injury (SCI). We have shown, however, that morphine administration in the early phase of SCI undermines ...
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Effects of Morphine on Activated Microglia and Macrophages in a Rodent Model of Spinal Cord Injury Terminel, Mabel N (2020-07-10)Opioids are among the most effective and commonly prescribed analgesics for the treatment of acute pain after spinal cord injury (SCI). We have shown, however, that morphine administration in the early phase of SCI undermines ...
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Effects of Morphine on Activated Microglia and Macrophages in a Rodent Model of Spinal Cord Injury Terminel, Mabel N (2020-07-10)Opioids are among the most effective and commonly prescribed analgesics for the treatment of acute pain after spinal cord injury (SCI). We have shown, however, that morphine administration in the early phase of SCI undermines ...
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Gomez, Francisco Pascual (2012-10-19)Multiple sclerosis (MS) is an idiopathic neurodegenerative, demyelinating disease of the central nervous system (CNS). MS affects females more than males (3:1) and pregnancy reduces the number of relapses especially during ...
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Lu, Jiayi (2020-09-07)The dorsomedial striatum (DMS) of the basal ganglia is critically involved in drug and alcohol abuse and contains medium spiny neurons (MSNs) expressing dopamine D1 receptors (D1Rs) or D2Rs. D1-MSNs positively and D2-MSNs ...
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Johnson, Andre (2019-05-07)Nearly three quarters of all strokes occur in people over 65, and within this older group, strokes are more common and more severe in women than men. Added to this disease burden, is the lack of suitable therapies for ...
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Sheth, Pari (2022-07-25)Multiple Sclerosis (MS) is one of the most debilitating autoimmune inflammatory disorders of the central nervous system (CNS). It is characterized by inflammatory demyelinating CNS lesions leading to profound physical and ...
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Jeong, Sehoon (2018-05-09)Neurological diseases are a major challenge to reach new therapies. However, physiological signals that regulate neurodegeneration in the central nervous system (CNS) are still little known since there is no suitable in ...
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Buonocore, John Edward (2017-05-08)Neurodegenerative diseases are extremely debilitating and affect a large portion of the population. Quality care for diseases such as multiple sclerosis relies heavily on the development of therapeutic agents by pharmaceutical ...
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Park, Jaewon (2012-02-14)In vertebrate nervous system, formation of myelin sheaths around axons is essential for rapid nerve impulse conduction. However, the signals that regulate myelination in CNS remain largely unknown partially due to the ...
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Bancroft, Eric Andrew (2022-11-08)Parkinson’s Disease (PD) is the second most common neurodegenerative disorder worldwide, with no known cure. The main pathological hallmark of PD is the loss of DA neurons within the substantia nigra pars compacta (SNc). ...
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Steelman, Andrew J; Li, Jianrong (Journal of Neuroinflammation, 2011)
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Thompson, Jeffrey (2012-12-01)Apoptosis is essential not only to the normal development of a multicellular organism but also for the maintenance of tissue homeostasis. This proposal seeks to investigate, in part, the role of oligodendrocyte (OL) ...
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Lu, Hsueh-Chung (2017-07-15)Multiple sclerosis (MS) is a debilitating disease characterized by demyelination and neurodegeneration in the CNS. Both activated microglia and infiltrating myeloid cells are thought to contribute to disease progression ...