Browsing by Author "Hwang, Wonmuk"
Now showing items 1-20 of 35
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Leow, Wee Wen (2012-07-16)Extracellular microenvironment, including its components and biophysical parameters such as matrix structure and stiffness, is a crucial determinant of cellular function. There exists interdependency between cellular ...
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Lakkaraju, Sirish Kaushik (2009-05-15)Elasticity of α-helices and coiled coils have often been described by a linear response to local bending with bending stiffness (Kb) and persistence length (Lp) describing their flexibility. However, we observed that the ...
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Characterization of Engineered Tissue by Multimodal Optical Imaging and Biaxial Mechanical Testing Bai, Yuqiang (2014-04-28)To better understand the relationships between mechanical stimuli and cellular responses, we developed a 3D tissue bioreactor coupling to both a biaxial mechanical testing platform and a stage for multimodal microscopy. ...
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Park, Jinseon (2011-10-21)In earlier research in our lab, the manipulation of microtubules on gold patterned silicon wafers was achieved by E-beam lithography, Poly (ethylene glycol) self assembled monolayers (PEG-SAMs) and electrophoresis. To ...
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Eryilmaz, Esma (2015-12-09)Collagen represents the most abundant protein family in the human body which forms 30% of the total protein. Among different types, type-I and type-III are the two most abundant, respectively, in the heterotypic fibril ...
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Fross, Sarah Elizabeth (2022-04-12)The Epstein-Barr virus (EBV) and Kaposi’s Sarcoma-associated herpesvirus (KSHV) are prevalent worldwide with a 95% infection rate for EBV and as high as 50% for KSHV in adults. These herpesviruses code for DNA Origin-Binding ...
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Chang Gonzalez, Ana Cristina (2023-05-16)Biological data is filled with rich information about complex and multifaceted processes, making it challenging to analyze and extract useful quantitative information. The purpose of this work is to develop and apply ...
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Chang Gonzalez, Ana Cristina (2023-05-16)Biological data is filled with rich information about complex and multifaceted processes, making it challenging to analyze and extract useful quantitative information. The purpose of this work is to develop and apply ...
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Shi, Jie (2021-07-05)The nonstructural protein 1 (NS1) of the 1918 Spanish influenza A virus hijacks N-terminal Src-homology 3 (nSH3) domain of host’s cellular CrkII with exceptionally high affinity through its proline-rich motif (PRM NS1). ...
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Kim, Taeyoon; Hwang, Wonmuk; Lee, Hyungsuk; Kamm, Roger D.; Fletcher, Daniel A. (PLoS Computational Biology, 2009)
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Lakkaraju, Sirish (2012-02-14)Alpha-helical coiled-coils are common protein structural motifs with varied mechanical roles, such as, tropomyosin in muscle contraction or neck-stalks of kinesins and myosins, in motor proteins. Using computer simulations, ...
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Mayuram Ravikumar, Krishnakumar (2012-10-19)Hydration is known to be crucial in biomolecular interactions including ligand binding and self-assembly. In our earlier studies we have shown the key role of water in stabilizing the specific parts of the collagen triple ...
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Gonzales, James Edward (2019-04-29)The purpose of this study was to explore and understand the behavior of microtubule protofilaments (MT PFs) in a dynamic environment through molecular dynamics simulations. MTs play a vital role in various cellular processes ...
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Namkoong, Myeong (2023-08-02)Soft electronic interfaces that match our skin properties show great potential in various applications, such as health monitoring, human-machine interface, and the Internet of Things. Both inorganic and organic conductive ...
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Martinez, Jonathan Anthony (2023-04-21)Non-invasive wearable devices introduce more convenient and fashionable alternatives for around-the-clock remote health monitoring at the beat-to-beat resolution throughout the varying contexts of patients’ daily activities ...
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Guo, Hong (2009-06-02)Mounting evidence suggests that the normal biomechanical state of arteries may include a nearly equibiaxial intramural stress, and that arteries tend to undergo rapid and dramatic remodeling when perturbed from this normal ...
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Na, Sungsoo (2009-06-02)The cytoskeleton is a diverse, multi-protein framework that plays a fundamental role in many cellular activities including mitosis, cell division, intracellular transport, cell motility, muscle contraction, and the regulation ...
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Meyer, Clark A. (2010-07-14)Abdominal aortic aneurysms (AAA) are an expansion in diameter of the abdominal aorta and their rupture is a leading cause of mortality. One of the treatments for AAA is the implantation of an endograft (also called a stent ...
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Nanda, Arnab (2017-05-09)he energy for sustaining life is released through the oxidation of glucose, fats, and proteins. A part of the energy released within each cell is stored as chemical energy of Adenosine Tri- Phosphate molecules, which is ...
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Davied, Eric (2013-12-06)Microtubules are filaments within cells that play important roles in intracellular transport, cell division, and overall structural support. Microtubules are composed of tubulin dimers of α- and β-tubulin. The dimers ...