Browsing by Author "Herman, Jennifer"
Now showing items 1-15 of 15
-
Brown, Emily E (2018-08-03)Bacillus subtilis is a soil bacterium capable of differentiating into a spore form resistant to both desiccation and heat. Sporulation begins with a single cell possessing two copies of a single, circular genome arranged ...
-
Sperber, Anthony Michael (2017-12-08)Bacterial growth and division requires the careful coordination of peptidoglycan (PG) synthesis and PG hydrolysis, allowing the insertion of new cell wall material at sites of active growth. In many rod-shaped bacteria, ...
-
Gorzelnik, Karl V (2014-05-02)Streptomycetes, as nonmotile microbes, are forced to adapt to environmental conditions they cannot escape. In order to adapt to their environment streptomycetes produce an array of both secondary metabolites to antagonize ...
-
Salazar, Adam Janton (2019-02-12)This dissertation covers projects focused on the drug design and characterization of novel bacterial drug targets. The first project centers on acetolactate synthase (ALS), a key enzyme involved in the biosynthesis of ...
-
Stubbendieck, Reed Michael (2017-05-02)Throughout history, especially beginning in the mid-twentieth century, humans have adapted numerous specialized metabolites produced by microbes as therapeutics. Since their inception, antibiotics have been a powerful tool ...
-
Ababneh, Qutaiba O (2015-08-10)The nucleotide second messengers pppGpp and ppGpp ((p)ppGpp) are responsible for the global down-regulation of transcription, translation, DNA replication, and growth rate during stringent response. More recent studies ...
-
Zhang, Chengxi (2020-07-30)In natural habitats, microorganisms synthesize specialized metabolites and enzymes that mediate chemical interactions between organisms. Those natural products have various biological activities, acting as signaling ...
-
Piya, Denish Kumar (2018-08-23)Evolution of phages and their bacterial hosts are directed by interaction between phage and host-encoded factors. These interactions have resulted in the development of several defense and counter-defense strategies such ...
-
Guo, Tingfeng (2022-12-07)Bacterial cell morphology plays important roles in nutrient absorption, cell growth, and pathogenesis, so understanding the determinants of morphology has the potential to significantly improve bioproduction, drug design ...
-
Sperber, Anthony; Herman, Jennifer (Journal of Bacteriology, 2017)
-
Rhee, Kathy Yeonjoo (2022-04-04)All major processes in living systems depend on energy sources. In bacteria undergoing cellular respiration, the central source of energy is the proton motive force (PMF). In addition to ATP synthesis, the PMF directly ...
-
Duan, Yi (2016-12-08)Bacteria precisely coordinate DNA replication and chromosome segregation with cell division; accurate regulation of each of these processes is critical to genome inheritance and thus reproductive success. During fast growth, ...
-
Ababneh, Qutaiba; Herman, Jennifer (Journal of Bacteriology, 2015)
-
Brehm, Joshua Neil (2021-05-19)CRISPR-Cas9 mutagenesis has been developed and proved to function in the bacterium Clostridioides difficile, albeit with efficiency and ease-of-use below the expected level. Here, we pursue two separate methods of improving ...
-
Duan, Yi; Sperber, Anthony; Herman, Jennifer (Journal of Bacteriology, 2016)