Browsing by Author "Gomer, Richard"
Now showing items 1-16 of 16
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Martinez, Elliott (2021-04-07)Phosphoinositides (PIPs) are phosphorylated derivatives of a membrane lipid called phosphatidylinositol that act as signaling molecules. These signaling molecules regulate hundreds of biological events ranging from growth, ...
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Triff, Karen (2016-01-13)During colon cancer development, epigenetic alterations contribute to the dysregulation of major cellular functions and signaling pathways. Recent evidence suggests that nutritionally chemoprotective components that influence ...
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Allen, Christina Pierrepont (2014-10-14)Cancer is a group of diseases characterized by uncontrolled cell proliferation. Cancer is responsible for nearly 1 of every 4 deaths, and ranks as the second highest cause of death worldwide, and costs the American population ...
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Constantine, Alexander (2013-02-04)Cellular movement in response to a chemical gradient, known as chemotaxis, is a critical behavior in many developmental and pathological processes such as embryo development and cancer metastasis. This cell movement can ...
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Cox, Nehemiah; Pilling, Darrell; Gomer, Richard (Proceedings of the National Academy of Sciences of the United States of America, 2015)
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Jiang, Zhengyang (2019-05-21)Cancer has become one of the biggest threats to human health. In most cases, cancer cells can be differentiated from normal tissues via the overexpression of certain cellular membrane proteins. Improved therapeutic effects ...
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Starke, Hannah (2012-04-12)Kidneys filter out toxins which accumulate in the blood. In order to replace the function of the kidneys in patients with kidney damage, fluid is injected into the abdominal cavity, and after 4-8 hours, during which the ...
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Chinea, Luis Enrique (2015-11-12)Wound treatment in the United States costs $25 billion annually (Sen, Gordillo et al. 2009) and one in a hundred people are hospitalized each year for a wound that requires professional medical attention (Drew, Posnett et ...
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Pilling, Darrell; Zheng, Zhichao; Vakil, Varsha; Gomer, Richard (Proceedings of the National Academy of Sciences of the United States of America, 2014)
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Chen, Qingquan (2019-07-12)Cystic fibrosis (CF) is a common, fatal, genetic disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. CF has many clinical manifestations. The most important site of disease ...
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Sump, Bethany Lyn (2015-09-16)In cancer patients, primary tumors can inhibit the proliferation of distant metastasized tumor cells. The subsequent removal of the primary tumor causes the metastasized tumor cells to regain the ability to proliferate. ...
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Xiang, Wang (2018-08-06)Macrophages are a heterogeneous population of cells and, include classically activated macrophages (M1) and alternatively activated macrophages (M2). Macrophages can change from M1 to M2 and vice versa in response to ...
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Suess, Patrick Michael (2018-05-07)Polyphosphate (polyP) is a linear polymer of orthophosphates linked by high energy phosphoanhydride bonds and is found in all cell types in nature. Despite this high conservation its role in cellular biology has remained ...
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Galvis Carvajal, Elkin David (2013-09-27)45% of deaths in the United States involve fibrosing diseases and the treatment of non-healing chronic wounds costs more than $25 billion annually in the United States alone. Scar tissue formation plays a critical role in ...
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Zhao, Bosheng (2020-04-08)Targeted therapy for cancer is a hot topic in recent years. Small molecule pharmaceuticals have advantages relative to antibodies with respect to cell penetration and affordability. This dissertation focuses on the application ...
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Thurman, Cory Calvin (2019-03-06)The cell wall is a common component found in nearly all bacteria. Long validated as a drug target for over half of all prescribed antibiotics, it continues to offer new sources for increasing that number ever further. ...