Browsing by Author "Criscitiello, Michael"
Now showing items 1-20 of 33
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Isaac, Alisa Helen (2022-06-23)Poly(ethylene glycol) (PEG) is a blank-slate biomaterial that is commonly used in pharmaceuticals, drug delivery, and tissue regeneration applications. However, there are growing concerns about PEG immunogenicity, and it ...
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Zychowski, Katherine E (2014-08-06)Clays have been used for centuries as ‘ancient medicine’ for their therapeutic benefits. One particular clay, calcium montmorillonite, has historically been used as an anti-caking agent in animal feeds, but has also ...
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Popp, Julia L (2021-07-26)Contemporary approaches for developing new interventions and for pre-clinical risk evaluation include assessments for cardiovascular structure and function, frequently performed in a variety of animal and in vitro models, ...
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Martin, Cameron Lee (2017-05-10)Lack of safe and effective adjuvants is a major hindrance to the development of efficacious vaccines. Signaling via CD40 pathway leads to enhanced antigen processing and presentation, nitric oxide expression, pro-inflammatory ...
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Lawley, Koedi Savannah (2022-07-28)A wide range of viruses cause immediate or delayed neurological manifestations in their hosts. Infection by neurotropic viruses as well as the resulting immune response can irreversibly disrupt the complex structural and ...
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Torres Odio, Sylvia (2023-07-10)Mitochondria are pleiotropic organelles integral to many processes including energy generation, cell death, signal transduction, and immunity. Consequently, mitochondrial dysfunction can significantly alter cell and tissue ...
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Torres Odio, Sylvia (2023-07-10)Mitochondria are pleiotropic organelles integral to many processes including energy generation, cell death, signal transduction, and immunity. Consequently, mitochondrial dysfunction can significantly alter cell and tissue ...
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Lokhandwala, Shehnaz Taher (2017-02-17)The objective of this work was to develop adenovirus-vectored prototype vaccines against two pathogens, African Swine Fever Virus (ASFV) and Bovine Viral Diarrhea Virus (BVDV), which cause disease in two major livestock ...
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Fisher, Colleen 1988- (2012-08-20)Genes modulating innate immunity in mammals are generally considered the first line of defense with respect to invading pathogens and therefore it has become important to characterize naturally occurring genetic variation, ...
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Weir, Heather; Chen, Patricia; Deiss, Thaddeus; Jacobs, Natalie; Nabity, Mary; Young, Matt; Criscitiello, Michael (Frontiers in Immunology, 2015)
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Georges, Hanah Michale (2017-07-26)Viral epidemics in the pork industry continue to plague the agricultural industry, national food security, and human health. Current preventative measures are insufficient for deterrence as viruses rapidly mutate and ...
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Arnold, Carolyn Elizabeth (2020-11-04)The microbiome of the equine gastrointestinal tract (GIT) form a symbiotic relationship with the horse, and play a critical role in nutrition, metabolism, and immunity. This work utilized 16S rRNA sequencing and metabolomics ...
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Vuong, Christine (2012-10-19)Although avian influenza virus (AIV) infections in domestic poultry are uncommon, transmission of avian influenza from wild waterfowl reservoirs does occur. Depopulation of the infected flock is the typical response to ...
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Mashoof, Sara (2014-04-15)Despite a large number of studies during the last decade that investigated mucosal immunity in humans, very few works have been done on this immune compartment in lower vertebrates. In the following two studies we focused ...
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Eltahan, Rana Abbas Khedr (2018-08-09)Cryptosporidium parvum is a water-borne and food-borne apicomplexan pathogen. It is one of the top four diarrheal-causing pathogens in children under the age of five in developing countries, and an opportunistic pathogen ...
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Exploring the Molecular Interactions Between Host Cells and Cryptosporidium parvum During Invasion Yu, Xue (2018-07-17)Cryptosporidium parvum is a zoonotic protozoan parasite belonging to the Phylum Apicomplexa and a causative agent of mild to severe watery diarrhea in humans and animals. The infection starts with the ingestion of oocysts, ...
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Seelye, Stacie Lynn (2016-05-05)In testing the hypothesis that all jawed vertebrate classes employ immunoglobulin heavy chain V (IgHV) gene segments in their T cell receptor (TCR)δ encoding loci, we found that some basic characterization was required of ...
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Investigating Singleminded 2s in Regulation of Breast Cancer Progression and Therapeutic Resistance Wyatt, Garhett Loftin (2022-08-17)Breast cancer is a leading cause of cancer-related death for women in the USA. Estrogen receptor positive breast cancers (ER+BC) comprise over 70% of BC cases and are targeted via ER modulation therapies. Despite this, ...
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Du, Christina (2012-10-19)The importance of gut associated lymphoid tissues has been extensively reported in higher vertebrates, but less is known in lower vertebrates. In mammals immunoglobulin (Ig)A is the primary Ig of mucosal immunity. But ...
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Shore, Ross Alan (2022-10-10)Respiratory syncytial virus (RSV) is the leading etiological factor for pneumonia, bronchiolitis, and post-bronchiolitic wheeze in children less than five years old. Besides palivizumab, an RSV prophylactic used for premature ...