Browsing by Author "Chapkin, Robert S"
Now showing items 1-20 of 29
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Triff, Karen (2016-01-13)During colon cancer development, epigenetic alterations contribute to the dysregulation of major cellular functions and signaling pathways. Recent evidence suggests that nutritionally chemoprotective components that influence ...
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Baek, Kyunghwa (2009-05-15)Mechanical unloading and food restriction (FR) are leading causes of bone loss, which increase the risk of fracture later in life. Leptin, a 16kDa cytokine like hormone principally produced by white adipocytes, may be ...
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Confocal Microscopy and Nuclear Segmentation Algorithm for Quantitative Imaging of Epithelial Tissue Harris, Meagan Alyssa (2015-07-08)Carcinomas, cancers that originate in the epithelium, account for more than 80% of all cancers. When detected early, the 5-year survival rate is greatly increased. Biopsy and histopathology is the current gold standard for ...
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Kelly, Kendra Marie (2013-12-05)Although significant research is currently being conducted to study human cancers, the use of in vivo models is time consuming and costly. Recent findings have documented the use of mouse intestinal crypt organoids as a ...
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Salinas, Michael Lee (2015-10-02)Approximately 30 to 50% of colorectal cancers contain KRas mutations, which confer resistance to standard therapy and have therefore been termed “undruggable.” Since no curative treatments for KRas driven colon cancer are ...
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Ritchie, Lauren E (2013-11-25)Microbial dysbiosis and toll-like receptor (TLR) signaling play a role in colonic injury and inflammation. Ulcerative colitis and radiation are known to alter microbiota, and diets containing polyphenols impact bacterial ...
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Kolar, Satya Sree N. (2009-05-15)Docosahexaenoic acid (DHA, 22:6n-3) from fish oil, and butyrate, a short-chain fatty acid fiber-fermentation product, protect against colon tumorigenesis in part by coordinately inducing apoptosis. We have demonstrated ...
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Gunaratna, Ramesh Tharindu (2018-05-01)Female breast cancer (BrCa) is the most common noncutaneous cancer among women in the United States. Human epidemiological studies reveal that p53 codon 72 single nucleotide variants, encoding proline (P72) or arginine ...
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Jung, Kyung Ho (2020-04-21)Cancer is the second leading cause of death in the world. It is responsible for 16% of death around the world, making it a major health concern in the 21th Century. Approximately, 18.1 million people were diagnosed with ...
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Lewis, Jayme Beth (2009-05-15)In order to test the dietary effects of bioactive compounds present in whole grains, we decided to observe the effect of varying types of sorghum bran on colon cancer promotion. We used 40 rats consuming diets containing ...
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George, Nysia I; Lupton, Joanne R; Turner, Nancy D; Chapkin, Robert S; Davidson, Laurie A; Wang, Naisyin (BMC Bioinformatics, 2010)
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Iadarola, Donna Marie (2021-04-09)How phospholipids are transported to different organelles within the cell is a major unsolved question in cell biology. To address this gap in knowledge, I utilized Saccharomyces cerevisiae as a model organism to study ...
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Salinas, Michael Lee (2022-04-22)The increasing prevalence of obesity and its associated risk of colorectal cancer (CRC) reinforces the urgent need to determine the underlying mechanisms contributing to the promotion of CRC in obese individuals. CRC is ...
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Deluca, Jennifer Agnes Alpha (2020-10-28)Inflammatory Bowel Diseases (IBDs) and Colorectal Cancers (CRC) are a complex collection of diseases with limited and invasive treatment options. Therefore, prevention is key but effective methods of doing so are elusive. ...
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Yoo, Gyhye (2015-11-19)Estrogen is a female sex hormone that has a variety of biologic actions via modulation of gene expression through estrogen receptors (ERs). The protective effect of estradiol (E2) and estrogen signaling in colon cancer has ...
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Schwartz, Scott; Friedberg, Iddo; Ivanov, Ivan V; Davidson, Laurie A; Goldsby, Jennifer S; Dahl, David B; Herman, Damir; Wang, Mei; Donovan, Sharon M; Chapkin, Robert S (GenomeBiology.com, 2012)
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Tang, Leung Kau (2017-05-05)Angiogenesis, the formation of new blood vessels from pre-existing ones, plays a crucial role in physiological processes and various pathological conditions including cancer. Angiogenic factor stimulation, including ...
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Shah, Manasvi Shailesh 1984- (2012-12-05)We have hypothesized that dietary modulation of intestinal miRNA expression may contribute to the chemoprotective effects of nutritional bioactives (fish oil and pectin). Using a rat colon carcinogen model, we determined ...
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Kim, Sammoon (2017-07-30)To examine mutual interactions between key mediators of inflammation and circadian clocks and their role in diet-induced metabolic disorders, we first determined whether circadian rhythm desynchronization exacerbates high ...
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Hou, Tim Yu-Tien (2014-12-05)Epidemiological and clinical studies have shown that very long chain n-3 polyunsaturated fatty acids (n-3 PUFA) such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) possess anti-inflammatory properties. The ...