Browsing by Author "Begley, Tadhg"
Now showing items 1-19 of 19
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Hazra, Amrita; Han, Andrew; Mehta, Angad; Mok, Kenny; Osadchiy, Vadim; Begley, Tadhg; Taga, Michiko (Proceedings of the National Academy of Sciences of the United States of America, 2015)
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McFarlin, Rae (2013-05-02)The development of methods for site-selective derivatization of natural products to enable simultaneous arming and structure activity relationship (SAR) studies has shown great potential for the synthesis of pharmaceutical ...
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Gorzelnik, Karl V (2014-05-02)Streptomycetes, as nonmotile microbes, are forced to adapt to environmental conditions they cannot escape. In order to adapt to their environment streptomycetes produce an array of both secondary metabolites to antagonize ...
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Xin, Dongyue (2016-02-22)Protein-protein interactions (PPIs) play key regulatory roles in biological systems, and some of these are interesting drug targets. Consequently, it is important to develop generally applicable methods to identify small ...
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Kundu, Nandini (2022-01-18)Nature is inherently homochiral. L-DNA and L-RNA, the enantiomeric forms of native D-DNA and D-RNA respectively, do not occur naturally and are virtually bioorthogonal. Compared to common chemical modifications, L-DNA/RNA ...
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Goble, Alissa M (2013-04-24)Improved sequencing technologies have created an explosion of sequence information that is analyzed and proteins are annotated automatically. Annotations are made based on similarity scores to previously annotated sequences, ...
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Crespo Morales, Roberto A (2017-12-05)The rapid emergence of drug-resistant Mycobacterium tuberculosis (Mtb) coupled to the high incidence of HIV-Mtb coinfection is of global concern. Consequently, there is a worldwide necessity to develop new drugs with novel ...
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Naseem, Saad (2022-01-06)Cofactors play vital roles in augmenting the limited functionality available on proteins for catalysis. Little is known about cofactor breakdown in contrast to the extensive literature on cofactor biosynthesis and enzymology. ...
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Hitchcock, Daniel Stephen (2014-02-24)High throughput sequencing technology and availability of this information has changed the way enzyme families can be studied. Sequence information from large public databases such as GenBank and UniProtKB can easily ...
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Hughes, Ryan C (2016-12-14)Current therapies for treatment of mycobacterial infections are adequate when diagnosis and pathology is well defined. Yet more evidence is beginning to accumulate for the multitude of reasons behind drug insensitive ...
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Washburn, Lauren Ashley (2020-05-18)The azinomycins are hybrid nonribosomal peptide and polyketide natural products isolated from Streptomyces sahachiroi. They are of interest due to their antitumor and broad antibiotic activity, which comes from the ability ...
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Patra, Shachin (2018-06-07)Iron-sulfur (Fe-S) clusters are essential cofactors and are found in all branches of life. In eukaryotes, Fe-S assembly complex is composed of NFS1, ISD11, ACP, ISCU2, and FXN subunits. NFS1 is a cysteine desulfurase that ...
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Cheng, Yu-Shan (2016-07-13)Tuberculosis (TB) killed 1.5 million people and rivaled AIDS, becoming the leading cause of death from infectious disease in 2014. The prevalence of multidrug resistant TB has intensified the current therapeutic procedure, ...
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Wang, Xiaoshan (2018-04-30)This study is composed of two parts. In the first part, we discussed nitrilimine-alkene cycloaddition for protein labeling. The mechanism of this nitrilimine-alkene cycloaddition was proposed, and thereby the best experimental ...
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Odoi, Keturah (2012-07-16)Systematic studies of basal nonsense suppression, orthogonality of tRNAPyl variants, and cross recognition between codons and tRNA anticodons are reported. E. coli displays detectable basal amber and opal suppression but ...
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Odoi, Keturah Amarkie (2016-10-07)Directly incorporating noncanonical amino acids (NCAAs) into proteins in living cells is an indispensible technique for investigating structures and functions of proteins. This co-translational insertion of NCAAs, which ...
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Messer, Kayla J. (2012-07-16)The main objective of this research was to develop a protocol in which pyridoxal phosphate (PLP) would act as a tag to identify PLP-dependent enzymes from complex mixtures or cell lysates. Following the purification of a ...
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Ma, Xinyu (2021-07-21)Structure-based drug design is a drug discovery strategy where rational design of drug molecules take place based on the structural information of therapeutic targets. With the development of structural biology technologies ...
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Khan, Danish (2018-08-06)Phosphatidylinositol Transfer Proteins are an enigmatic family of proteins present across the plant and animal kingdoms. They act as diversifiers of phosphoinositide signaling and regulate diverse cellular processes such ...