Browsing by Author "Polymenis, Michael"
Now showing items 21-40 of 59
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Wahlman, Judit (2009-05-15)Secretory proteins that are unable to assemble into native proteins in the endoplasmic reticulum (ER) are transported back into the cytosol for degradation. Many cytosolic and ER resident proteins have been identified so ...
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Han, Bong Kwan (Texas A&M University, 2007-04-25)How proliferating cells maintain the copy number and overall size of their organelles is not clear. In the budding yeast Saccharomyces cerevisiae the G1 cyclins Cln1,2,3p control initiation of cell division by regulating ...
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Mella Herrera, Rodrigo Andres (2010-10-12)Many multicellular cyanobacteria produce specialized nitrogen-fixing heterocysts. During diazotrophic growth of the model organism Anabaena (Nostoc) sp. strain PCC 7120, a regulated developmental pattern of single ...
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Aldea, Maria Ramona (2009-05-15)The regulatory mechanisms that govern heterocyst development in Anabaena sp. strain PCC 7120 have been continuously refined over the last two decades. In this work, we show that three of the sigma factor genes present in ...
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Wang, Shanzhi (2011-10-21)Tyrosine hydroxylase (TyrH) is the first and rate-limiting enzyme of catecholamine synthetic pathway, and its regulation is critical for controlling catecholamine synthesis. The well recognized regulatory mechanisms are ...
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Kagiampakis, Ioannis (2011-10-21)In the first part of my dissertation we focused on the development of covalently linking compounds that bind gp120 with those that bind gp41 in order to block HIV fusion. We used griffithsin or CD4M33, that both bind to ...
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Malik, Indranil (2017-07-28)Gene transcription by RNA polymerase II (Pol II) is an essential process. Using Saccharomyces cerevisiae as a model system, our lab has previously identified and partially characterized Pol II activity mutants that can ...
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Blank, Heidi M.; Li, Chonghua; Mueller, John E.; Bogomolnaya, Lydia M.; Bryk, Mary; Polymenis, Michael; Cohen-Fix, Orna (PLoS Genetics, 2008)
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Suess, Patrick Michael (2018-05-07)Polyphosphate (polyP) is a linear polymer of orthophosphates linked by high energy phosphoanhydride bonds and is found in all cell types in nature. Despite this high conservation its role in cellular biology has remained ...
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Wu, I Fan (2021-06-04)Following classical genetic approaches to understanding gene function, high-throughput phenotyping methods have emerged as a new way of studying gene functions, especially in microorganisms, which are highly amenable to ...
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Weers, Brock D. (2012-10-19)The growth and development of two sorghum drought tolerant genotypes BTx642 (post-flowering drought tolerant, “stay green”) and RTx7000 (pre-flowering drought tolerant) were characterized and compared. Differences in ...
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Arabiotorre Duran, Angela Arantza (2023-02-27)Phosphoinositides (PIPs) are a biologically essential class of phospholipids that contribute to organelle membrane identity, modulate membrane trafficking pathways, and are central components of major signal transduction ...
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Blank, Heidi M. (2010-07-14)The longstanding view has been that metabolism allows for cell division to take place, but that metabolic processes do not actively promote cell division. I have recently challenged this notion by identifying a unique ...
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Herlihy, Sarah E (2014-06-05)The work in this dissertation links two diseases through a protein secreted by Dictyostelium discoideum cells. The protein, AprA, inhibits cell proliferation and induces chemorepulsion (movement away) of Dictyostelium ...
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Gong, Xue (2022-07-25)Solutes and nutrients are internalized by endocytosis and delivered to early endosomes in membranous transport carriers in eukaryotic cells. The release of these carriers into the cell requires membrane fission proteins. ...
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Krenek, Keith (2015-05-07)The mechanisms and causes of aging, the greatest risk factor of disease, are poorly understood. This lack of knowledge—specifically in relation to the aging of single biological cells—results from limitations in the methods ...
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Qu, Xiaotao (2011-02-22)Predicting protein structure using its primary sequence has always been a challenging topic in biochemistry. Although it seems as simple as finding the minimal energy conformation, it has been quite difficult to provide ...
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Soma, Shivatheja Reddy (2019-07-24)Copper is required for the activity of cytochrome c oxidase (CcO), the mitochondrial enzyme that catalyzes cellular respiration. Copper delivery to CcO is a complex process requiring a number of proteins, and loss-of-function ...
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Zweifel, Adrienne Elizabeth (2011-08-08)Protein oligomerization provides a way for cells to modulate function in vivo. In this study, self-assembling protein fragments from ParC, DnaX, and proteins of unknown function were used to generate phenotypes in a ...
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Ghosh, Sagnika (2021-10-28)Biochemical interactions between macromolecules form the basis of life. Among different macromolecular interactions present in living systems, we still lag in our understanding of how lipids influence the structure and ...