Browsing by Author "Safe, Stephen"
Now showing items 41-57 of 57
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Wang, Haiqing (2017-04-19)Fetal alcohol spectrum disorders (FASD) are a spectrum of pathophysiological consequences that include structural, neurological and behavior disorders that arise following prenatal alcohol exposure (PAE). Work by our group ...
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Pinkerton, Terrence Scott (Texas A&M University, 2005-08-29)Organophosphate hydrolase (OPH, EC 3.1.8.1) is a bacterial enzyme with a broad spectrum of potential substrates that include organophosphorus pesticides, herbicides, and chemical warfare agents. OPH has been expressed ...
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Park, Yun-Yong; Kim, Kyounghyun; Kim, Sang-Bae; Hennessy, Bryan; Soo Mi Kim; Eun Sung Park; Jae Yun Lim; Li, Jane; Lu, Yiling; Ana Maria Gonzalez-Angulo; Jeong, Woojin; Mills, Gordon; Safe, Stephen; Lee, Ju-Seog (EMBO Molecular Medicine, 2012)
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Mitchell, Dianne Courtenay (Texas A&M University, 2007-09-17)Modulation of the actin-based cytoskeleton and transcription factor regulation are merely two essential functions in a wide array of cellular activities that the Rho family of small GTPases is responsible for mediating. ...
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Scribner, Kelly C (2013-05-21)Ductal carcinoma in situ (DCIS) has been shown to be a precursor to invasive ductal cancer (IDC). Though the progression of DCIS to IDC is believed to be an important aspect of tumor aggressiveness, prognosis and molecular ...
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Wellberg, Elizabeth (2010-07-14)Sim2s is a basic helix-loop-helix Per-Arnt-Sim (bHLH-PAS) transcription factor. In Drosophila, the Sim2 homolog, sim, is necessary for cell fate determination during central nervous system (CNS) development. In mammals, ...
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Ying, Wei (2015-02-02)The recruitment of immune cells into adipose tissue is a hallmark of obesity and a key event contributing to the development of adipose tissue inflammation and insulin resistance. However, the mechanisms regulating functions ...
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Ferguson, Brent Wade (2012-02-14)Heparan sulfate proteoglycans modulate many of the growth factor pathways that drive prostate cancer progression. Prior to being secreted into the extracellular matrix, the covalently attached HS chains are modified by ...
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Pan, Quan (2020-11-20)Liver and adipose tissue are crucial for blood glucose and energy homeostasis, while unsuppressed hepatic glucose production (HGP) causes hyperglycemia and imbalanced energy expenditure could lead to excessive fat storage ...
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Al Muhisen, Hadil Mahdi J (2018-08-08)Fetal Alcohol Spectrum Disorders (FASDs) can result from prenatal exposure to alcohol. Alcohol is a known teratogen and in utero exposure is the leading non-genetic cause of neurodevelopmental disabilities. Neural stem ...
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Schoeller, Abigail (2021-12-10)Breast cancer is one of the most common cancers affecting women in the United States. Hormone receptor positive (HR+) breast tumors are the most prevalent, accounting for 70% of breast cancer cases. Therapies that target ...
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Li, Xi; Pathi, Satya; Safe, Stephen (BMC Cancer, 2015)
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Banerjee, Nivedita (2011-10-21)Although nano-sized metal colloids are used in industrial and medicinal applications, little is known about the potential liver toxicity of these materials after occupational or intentional exposures. To begin to resolve ...
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Schilling, Lauren 1984- (2010-08-26)Singleminded-2s (Sim2s) is a member of the basic helix-loop-helix Per-Arnt-Sim (bHLH-PAS) family of transcription factors. Members of this family play important roles in sensing and responding to environmental changes, ...
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Kanameni, Srikanth (2015-04-17)Adipose tissue macrophages (ATMs) are pivotal regulators for adipose tissue function, specifically contributing to the homeostasis of the adipose niche. Significantly increased ATMs and their altered activation patterns ...
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Xie, Ying (2011-08-08)Pregnane X receptor (PXR) is a ligand-dependent transcription factor that plays an important role in xenobiotic/drug metabolism. The ligand-receptor interaction transcriptionally activates phase I and phase II enzymes, and ...
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Tjalkens, Ronald B.; Safe, Stephen (United States. Patent and Trademark Office; Texas A&M University. Libraries, 2013-11-12)Presented herein are diindolylmethane derivative compounds useful for the prevention and or treatment of neurological conditions, including neurological conditions related to neuroinflammation. One such neurological condition ...