Browsing by Author "Tian, Yanan"
Now showing items 21-36 of 36
-
Villarreal, Daniel (2019-07-29)Type 2 diabetes is characterized by insulin resistance and beta-cell dysfunction[1]. Macrophages are a major source of inflammatory cytokine IL-1β, which is a major regulator of inflammation in the pancreatic beta-cells ...
-
Jia, Qian 1980- (2011-07-30)Bioactive food components containing n-3 polyunsaturated fatty acids (PUFA) and curcumin modulate multiple determinants that link inflammation to cancer initiation and progression. In this dissertation, both transgenic and ...
-
Eagleton, Navada Lorraine (2011-10-21)To understand the mechanisms of transcriptional regulation of PXR, we performed yeast two-hybrid screenings to search for PXR-interacting proteins in a human liver cDNA library using the PXR ligand binding domain as the ...
-
Fuentes, Natividad R (2017-12-14)Approximately 30-50% of colorectal cancers contain KRas mutations, which confer resistance to standard therapy. A diet high in long-chain n-3 polyunsaturated fatty acids (n-3 PUFA) is generally considered chemoprotective ...
-
Banerjee, Nivedita (2013-12-11)Cancer is a major cause of death worldwide. Hence, there is a great need to develop novel therapeutic agents for the prevention and treatment of cancer in addition to conventional therapies. Dietary polyphenols are known ...
-
Wu, Mingqi (2011-02-22)This dissertation research consists of two topics, population stochastics approximation Monte Carlo (Pop-SAMC) for Baysian model selection problems and ChIP-chip data analysis. The following two paragraphs give a brief ...
-
Francis Stuart, Samantha D. (2014-05-06)Cadmium (Cd) is a toxic heavy metal with no known physiological function in higher order animals. Previous studies in primary cultures of neonatal rat choroid plexus (CP) epithelial cells indicated Cd induced oxidative ...
-
Gu, Xinsheng (2009-05-15)Cytochrome P450 3A4 (CYP3A4) is a key enzyme responsible for the metabolism of drugs and endogenous compounds in human liver and intestine. CYP3A4 gene expression is mainly regulated by Pregnane X receptor (PXR) which is ...
-
Chen, Jingshu (2020-03-27)The metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a long noncoding RNA and its overexpression is associated with poor prognosis of many types of cancers and its silencing has been reported to reverse ...
-
The Role of Long Noncoding RNAs in Cancer and Microbiota-derived Aryl Hydrocarbon Receptor Ligands Cheng, Yating (2016-12-06)LncRNAs are a group of non-coding RNAs containing >200 nucleotides and these RNAs have no significant protein coding potential. In the past 10-15 years the role of lncRNAs in cancers have been demonstrated, however, their ...
-
Suchodolski, Paulette F. (2010-07-14)Marek's disease virus (MDV), the etiologic agent of Marek's disease, is a potent oncogenic herpesvirus. MDV is highly contagious and elicits a rapid onset of malignant T-cell lymphomas in chickens within several weeks after ...
-
Verkhoturov, Dmitriy S (2020-08-28)Nanoscale toxins and pollutants such as ultrafine particles and metals from the environment can enter the human body and interact with host membrane proteins disrupting normal metabolism either directly or by causing changes ...
-
Banerjee, Nivedita (2011-10-21)Although nano-sized metal colloids are used in industrial and medicinal applications, little is known about the potential liver toxicity of these materials after occupational or intentional exposures. To begin to resolve ...
-
Naspinski, Christine S. (2010-01-16)Polycyclic aromatic hydrocarbons (PAHs) are widely distributed in the environment and are generated by many sources. Though the potential of PAH-rich mixtures to cause health effects has been known for almost a century, ...
-
Xie, Ying (2011-08-08)Pregnane X receptor (PXR) is a ligand-dependent transcription factor that plays an important role in xenobiotic/drug metabolism. The ligand-receptor interaction transcriptionally activates phase I and phase II enzymes, and ...
-
Wang, Meichen (2016-05-24)Pregnane X receptor (PXR) is a ligand-activated nuclear receptor that regulates gene expression of the metabolizing enzymes that are involved in detoxification of endogenous and exogenous compounds in the gastrointestinal ...