Browsing by Author "Safe, Stephen"
Now showing items 21-40 of 57
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Davis, De Ann Marie Pospisil (Texas A&M University. Libraries, 1989)The role of the aryl hydrocarbon (Ah) receptor in mediating the immunosuppressive effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) and related halogenated aromatic hydrocarbons (HAHs) on the murine splenic ...
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Inhibition of breast and prostate cancer cell growth by 3,3'-diindolylmethane and related compounds Kotha, Leela (2009-05-15)Selective receptor modulators have been developed for steroid hormone receptors as a new class of mechanism-based drugs for treatment of hormone related diseases. We investigated an alternative mechanism-based strategy ...
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Ying, Wei; Kanameni, Srikanth; Chang, Cheng-An; Nair, Vijayalekshmi; Safe, Stephen; Bazer, Fuller W.; Zhou, Beiyan; Zissel, Gernot (PloS One, 2014)
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Pathi, Satya (2012-10-19)Non-steroidal anti-inflammatory drugs (NSAIDs) and their NO derivatives (NO-NSAIDs), and synthetic analogs are highly effective as anticancer agents that exhibit relatively low toxicity compared to most clinically used ...
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Wu, Qian (2009-05-15)Vitamin D interacting protein 205 (DRIP205) is a mediator complex protein that anchors the complex to the estrogen receptor (ER) and other nuclear receptors (NRs). In ZR-75 breast cancer cells treated with 17?-estradiol (E2) ...
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Liu, Xinyi (2012-10-19)Tolfenamic acid (TA), betulinic acid (BA) and acetylsalicylic acid (aspirin) are anticancer drugs, and Sp1, Sp3, Sp4 transcription factors and growth factor 2 (EGFR2, HER2 / ErbB2) are important molecular markers in cancer ...
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Biegel, Lisa Benton (Texas A&M University. Libraries, 1990)Two polychlorinated biphenyl congeners, namely 2,2',4,4',5,5',-hexa- and 2,2',5,5'-tetrachlorobiphenyl and MCDF antagonized 2,3,7,8-TCDD-induced deft palate in C57BL/6 mice. Administration of [³H]-2,3,7,8-TCDD to C57BL/6 ...
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Ying, Wei; Tseng, Alexander; Richard Cheng-An Chang; Wang, Haiqing; Lin, Yu-lieh; Kanameni, Srikanth; Brehm, Tyler; Morin, Andrew; Jones, Benjamin; Splawn, Taylor; Criscitiello, Michael; Golding, Michael; Bazer, Fuller; Safe, Stephen; Zhou, Beiyan (Scientific Reports, 2016)
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Anchin, Jerry (Texas A&M University. Libraries, 1993)A combination of biophysical measurements and knowledge-based computer-aided molecular modeling of antibody binding sites was used to predict the interactions between high affinity monoclonal antibodies and an intensely ...
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Tang, Su (2018-11-02)The methylcitrate cycle and glyoxylate bypass are two critical pathways of the central carbon metabolism of the human pathogen Mycobacterium tuberculosis (Mtb). Transcription of the key enzymes in these pathways is controlled ...
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Chintharlapalli, Sudhakar Reddy (Texas A&M University, 2007-09-17)1,1-Bis(3'-indolyl)-1-(p-substitutedphenyl)methanes containing ptrifluoromethyl (DIM-C-pPhCF3), p-t-butyl (DIM-C-pPhtBu), and phenyl (DIM-CpPhC6H5) substituents have been identified as a new class of peroxisome ...
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Eagleton, Navada Lorraine (2011-10-21)To understand the mechanisms of transcriptional regulation of PXR, we performed yeast two-hybrid screenings to search for PXR-interacting proteins in a human liver cDNA library using the PXR ligand binding domain as the ...
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Hedrick, Erik; Lee, Syng-Ook; Doddapaneni, Ravi; Singh, Mandip; Safe, Stephen (Molecular and Cellular Biology, 2016)
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Lacey, Alexandra Dianne (2017-08-03)Rhabdomyosarcoma (RMS) is a pediatric cancer for which common therapeutics include cytotoxic chemotherapeutics that result in adverse health outcomes later in adulthood. Previous studies have found NR4A1 expression contributes ...
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Hedrick, Erik; Lee, Syng-Ook; Kim, Gyungeun; Abdelrahim, Maen; Jin, Un-Ho; Safe, Stephen; Abudayyeh, Ala; Datti, Alessandro (PloS One, 2015)
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Shrestha, Rupesh (2021-12-09)Nuclear receptor 4A1 (NR4A1) is an orphan receptor that is overexpressed in several cancers and is known for its pro-oncogenic activities in solid tumors. NR4A1 plays a crucial role in multiple cancers and regulates ...
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Guthrie, Aaron S 1987- (2012-12-05)Isothiocyanates (ITCs) are phytochemicals highly expressed in cruciferous vegetables and these compounds are associated with the decreased incidence of cancers in populations consuming high levels of cruciferous vegetables. ...
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Banerjee, Nivedita (2013-12-11)Cancer is a major cause of death worldwide. Hence, there is a great need to develop novel therapeutic agents for the prevention and treatment of cancer in addition to conventional therapies. Dietary polyphenols are known ...
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Nemec, Matthew James (2016-08-01)More than 25% of all newly diagnosed breast cancer cases are ductal carcinoma in situ (DCIS), the most commonly diagnosed form of non-invasive breast cancer. This incidence coupled with the detrimental side effects associate ...
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Warren, Melanie Renai (2019-04-15)Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin) during pregnancy is of particular concern as it interrupts fetal growth and development. While susceptibility to many toxicants often varies among individuals ...