Browsing by Author "Sacchettini, James C."
Now showing items 21-40 of 51
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Freundlich, Joel S.; Sacchettini, James C.; Kriger, Inna V.; Ioerger, Thomas R.; Gawandi, Vijay (United States. Patent and Trademark Office; Texas A&M University. Libraries, 2014-03-04)The present invention provides aryl- or heteroaryl-diketo acid compounds effective to inhibit an activity of a Mycobacterial malate synthase enzyme or to inhibit a malate synthase activity in other bacteria having the ...
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Funck, Edward Sterling (2012-07-16)Despite an ever growing number of reports concerning the anion-π interaction, controversy surrounding the nature of these weak supramolecular interactions continues. In an effort to further explore the nature and properties ...
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Cheng, Yu-Shan (2016-07-13)Tuberculosis (TB) killed 1.5 million people and rivaled AIDS, becoming the leading cause of death from infectious disease in 2014. The prevalence of multidrug resistant TB has intensified the current therapeutic procedure, ...
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Palaninathan, Satheesh K.; Mohamedmohaideen, Nilofar N.; Orlandini, Elisabetta; Ortore, Gabriella; Nencetti, Susanna; Lapucci, Annalina; Rossello, Armando; Freundlich, Joel S.; Sacchettini, James C.; Hofmann, Andreas (PloS One, 2009)
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Small, Jennifer L.; Park, Sae Woong; Kana, Bavesh D.; Ioerger, Thomas R.; Sacchettini, James C.; Ehrt, Sabine (MBio, 2013)
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Adams, Paul D.; Grosse-Kunstleve, Ralf W.; Hung, Li-Wei; Ioerger, Thomas R.; McCoy, Airlie J.; Moriarty, Nigel W.; Read, Randy J.; Sacchettini, James C.; Sauter, Nicholas K.; Terwilliger, Thomas C. (Acta Crystallographica. Section D - Biological Crystallography, 2002)
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Adams, Paul D.; Gopal, Kreshna; Grosse-Kunstleve, Ralf W.; Hung, Li-Wei; Ioerger, Thomas R.; McCoy, Airlie J.; Moriarty, Nigel W.; Pai, Reetal K.; Read, Randy J.; Romo, Tod D.; Sacchettini, James C.; Sauter, Nicholas K.; Storoni, Laurent C.; Terwilliger, Thomas C. (Journal of Synchrotron Radiation, 2003)
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Ngwenya, Sharon Khethiwe (Texas A&M University, 2005-08-29)17β-Estradiol induces E2F-1 gene expression in ZR-75 and MCF-7 human breast cancer cells. Analysis of the E2F-1 gene promoter in MCF-7 cells previously showed that hormone-induced transactivation required interactions between ...
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Kuty, Gabriel (2012-02-14)SAR endolysins are a recently discovered class of muralytic enzymes that are regulated by dynamic membrane topology. They are synthesized as enzymatically inactive integral membrane proteins during the phage infection cycle ...
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Deaton, John Franklin (Texas A&M University, 2004-11-15)The 105aa lambda S protein is the prototype holin, S accumulates in the cytoplasmic membrane during late gene expression until, at a time programmed into its primary structure, it disrupts the membrane and allows the lambda ...
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Zhu, Wan Wen (2012-10-19)MshA is a glycosyltransferase that synthesizes the precursor of mycothiol, a low-molecular-weight thiol found exclusively in Actinomycetes, including the virulent pathogen Mycobacterium tuberculosis (Mtb). The structure ...
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Tsai, Chi-Lin (2012-07-16)Iron-sulfur (Fe-S) clusters are critical protein cofactors found in all life forms. In eukaryotes, a well-conserved biosynthetic pathway located in the mitochondria is used to assemble Fe-S clusters. Although proteins ...
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Lucumi Moreno, Edinson (Texas A&M University, 2007-04-25)Malaria is a disease that causes more than 1 million deaths per year world wide and more than 400 million clinical cases. Due to the acquired resistance of Plasmodium falciparum to the drugs used to control the infection, ...
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Dey, Sanghamitra (2009-05-15)Mycobacterium tuberculosis (Mtb) utilizes different metabolic pathways for its survival during infection. Enzymes of these pathways are often targets for antibiotic development. Genetic studies indicate the importance of ...
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Ramachandran, Rajesh (Texas A&M University, 2006-04-12)Perfringolysin O (PFO), a cytolytic toxin from by the pathogenic bacterium Clostridium perfringens, perforates mammalian cell membranes by forming large aqueous pores. Secreted as water-soluble monomers, the toxin molecules ...
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Sun, Qingan (2011-08-08)Structural biology lays the molecular foundation for the modern field of life sciences. In this thesis, X-ray crystallography is the primary resource for atomic detail structural information and is the major technology ...
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Yu, Hong (2009-05-15)Catalase-peroxidase (KatG) of Mycobacterium tuberculosis is a bifunctional heme enzyme that has been shown to play an important role in the activation of a first line drug, isoniazid (INH), used in the treatment of ...
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Yang, Dong (2009-06-02)The objective of this work is to investigate the structures of two nucleotide binding proteins: mevalonate kinase (MVK) and FtsZ. MVK is the key enzyme involved in terpenoid biosynthesis. In this study, we solved the crystal ...
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Ramesh, Arati (2009-05-15)Ro ribonucleoproteins are antigenic protein-RNA particles that are the major targets of the immune reaction in autoimmune disorders like systemic lupus erythematosus. The Ro protein has been implicated in cellular RNA ...
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Kuo, Mack Ryan (2009-05-15)Malaria and tuberculosis constitute two of the world’s deadliest infectious diseases. Together, they afflict over one third of the world’s population. Once thought of as one of a group of nearly vanquished diseases only ...