Browsing by Subject "Cancer"
Now showing items 1-20 of 40
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A Microfluidic Model to Study Host-Microbiota Interactions in the Colorectal Tumor Microenvironemnt (2022-11-29)The colonic microbiota has been identified as a key player in the development of colorectal cancer. While changes in microbiota composition and function correlate with disease progression and treatment outcome, the mechanism ...
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(2018-11)For scholars and policymakers alike, understanding the burden of cancer on society is a critical topic for investigation. Cancer consistently ranks as the second leading cause of death in the U.S., and cancers of the ...
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(2015-11-02)Controlling metastatic and invasive tumors is the challenging part of treating cancer. The overall aim of this dissertation was to target these aggressive cells, called tumor-initiating cells (TICs). They exploit embryonic ...
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Understanding the dynamic balance between protein synthesis and degradation is critical in characterizing skeletal muscle growth, maintenance, or wasting. Over 160,000 people in the United States suffer from Cachexia, a ...
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(Texas A&M University. Libraries, 1984)Human prostate cancer has a 17% incidence in men over 55 years of age, with only a 55% survival rate after 5 years of treatment. Presently, no diagnostic procedure is very effective in detecting the early stages of prostatic ...
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(2018-06-01)Cancer is a disease associated with uncontrolled cell proliferation or reduced cell death, either of which can lead to tumorigenesis. A possible route through which cancer can develop is by breakdowns in the signaling ...
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(2018-08-09)Glioblastoma multiforme (GBM) is a highly lethal cancer arising from mutations in glial cells. Many therapies currently in development for this disease focus on the role of the immune system and its inability to interact ...
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(2018-05-03)The early diagnosis of oral carcinoma has proven to be a difficult task. Fully developed oral squamous cell carcinomas can be easily recognized by trained clinicians due to the appearance of aggressive exogenous tumors and ...
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(2021-09-01)Epigenetic alterations, such as changes in DNA methylation, histones/chromatin structure, nucleosome positioning, and expression of non-coding RNAs, are recognized among key characteristics of carcinogens; they may occur ...
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(2015-02-19)Thyroid stimulating hormone (TSH) is an important endocrine hormone of the pituitary affecting metabolism, development, and immunity. However, TSH has lesser known roles in other bodily processes. Cells of the peripheral ...
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(BioMed Central Ltd., 2014-06-09)Despite recommendations for cancer screening for breast and colorectal cancer among the Medicare population, preventive screenings rates are often lower among vulnerable populations such as the small but rapidly growing ...
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(2016-11-03)Ultrasound elastography (USE) is a well-established technique used to non-invasively map tissue stiffness. More recently, a novel branch of USE, called poroelastography, has been proposed, which aims at estimating the ...
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(2020-04-21)The primary objective of this project is to use a neural network (deep learning) model that will be trained on datasets of human cells in mitosis and then apply it on animal cells using transfer learning techniques. The ...
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(Texas A&M University. Libraries, 1986)One of the important aspects of quantitative cancer risk assessment is to model the frequency of a carcinogenic response as a function of exposure. Most of the current time-to-response modeling has been done using the ...
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(2012-02-14)Activation of G-protein coupled receptor 54 (GPR54) signaling generated by kisspeptins (endogenous GPR54 ligands encoded by KISS1 gene) has been known to regulate puberty and to suppress cancer metastasis. However, an ...
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(2015-06-03)Fibrosis is a disease in which scar tissue invades healthy organs and reduces their function. Fibrosis is involved in 45% of deaths in the United States, yet little is known about the signaling that underlies the early ...
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(2013-11-18)Signaling pathway analysis is so important to study the causes of diseases and the treatment of drugs. Finding the lurking pathway from ligand to signature is a significant issue in studying the mechanism of how the cell ...
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(2014-05-07)Cancer accounts for one in eight deaths worldwide and one in four deaths in the United States. Chemotherapy is the most common treatment option for cancer; however, many chemotherapeutic drugs have toxic side effects. Our ...
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(2012-10-19)Non-steroidal anti-inflammatory drugs (NSAIDs) and their NO derivatives (NO-NSAIDs), and synthetic analogs are highly effective as anticancer agents that exhibit relatively low toxicity compared to most clinically used ...