Browsing by Author "Hu, James C."
Now showing items 1-20 of 21
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Zhou, Min (Texas A&M University, 2005-02-17)Isolated from marine sponges, many bromopyrrole alkaloids have become natural products of intense scientific interest. The oroidin-derived class of dimeric bromopyrrole alkaloids that include ageliferin, bromoageliferin, ...
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Lee, Ya-Jung (2012-07-16)Cell-penetrating peptides (CPPs) mediate the delivery of macromolecules across the plasma membrane of live cells. These peptides are therefore important due to the potential of making the delivery of protein probes or ...
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Liu, Yiquan (2015-10-28)Activity based protein profiling (ABPP) is a functional proteomic technology that uses chemical probes to detect mechanistically related classes of enzymes. Chemically probing a certain class of proteins helps to understand ...
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Ruotolo, Brandon Thomas (Texas A&M University, 2005-08-29)Separations coupled to mass spectrometry (MS) are widely used for large-scale protein identification in order to reduce the adverse effects of analyte ion suppression, increase the dynamic range, and as a deconvolution ...
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Rieker, Jennifer Dawn (1998)The dimerization specificity of a leucine zipper is partially determined by the interactions of charged amino acids on the surfaces of dimer interfaces (e and g positions). A series of e and g position GCN4 mutants has ...
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Singleton, Michael Lee (2012-02-14)The unique active site of [FeFe]-hydrogenase has inspired over 300 small molecule models derived from the classical organometallic complex, (μ-SRS-)[Fe(CO)3]2. However, no model complex has yet reproduced the hydrogen ...
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Quinlan, Robert Jason (Texas A&M University, 2005-02-17)Protein-ligand and protein-protein interactions are critical to cellular function. Most cellular metabolic and signal tranduction pathways are influenced by these interactions, consequently molecular level understanding ...
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Williams, Brad J. (2011-08-08)Disulfide bonds play important roles in establishing and stabilizing three-dimensional protein structure, and mass spectrometry (MS) has become the primary detection method to decipher their biological and pathological ...
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Zweifel, Adrienne Elizabeth (2011-08-08)Protein oligomerization provides a way for cells to modulate function in vivo. In this study, self-assembling protein fragments from ParC, DnaX, and proteins of unknown function were used to generate phenotypes in a ...
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Kuty, Gabriel (2012-02-14)SAR endolysins are a recently discovered class of muralytic enzymes that are regulated by dynamic membrane topology. They are synthesized as enzymatically inactive integral membrane proteins during the phage infection cycle ...
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Diaz Vazquez, Arnaldo Joel (2009-05-15)This dissertation focuses on the development of biological platforms on which the function and characterization of transmembrane proteins can be performed simultaneously utilizing a biomembrane mimic consisting of a solid ...
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Saksena, Suraj (Texas A&M University, 2006-04-12)The current "diffusion-retention" model for protein trafficking to the inner nuclear membrane (INM) proposes that INM proteins diffuse laterally from the membrane of the endoplasmic reticulum into the INM and are then ...
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Knapp, Gwendowlyn S.; Hu, James C.; Herman, Christophe (PloS One, 2010)
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Fischer, Tiffany Brink (Texas A&M University, 2007-04-25)Here, we present the program QContacts, which implements Voronoi polyhedra to determine atomic and residue contacts across the interface of a protein-protein interaction. While QContacts also describes hydrogen bonds, ionic ...
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Mosser, Rockann Elizabeth (2011-10-21)Bacillus stearothermophilus phosphofructokinase (BsPFK) is a homotetramer that is allosterically inhibited by phosphoenolpyruvate (PEP), which binds along one dimer-dimer interface. The substrate, fructose-6-phosphate ...
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Lucumi Moreno, Edinson (Texas A&M University, 2007-04-25)Malaria is a disease that causes more than 1 million deaths per year world wide and more than 400 million clinical cases. Due to the acquired resistance of Plasmodium falciparum to the drugs used to control the infection, ...
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Yang, Dong (2009-06-02)The objective of this work is to investigate the structures of two nucleotide binding proteins: mevalonate kinase (MVK) and FtsZ. MVK is the key enzyme involved in terpenoid biosynthesis. In this study, we solved the crystal ...
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Ramesh, Arati (2009-05-15)Ro ribonucleoproteins are antigenic protein-RNA particles that are the major targets of the immune reaction in autoimmune disorders like systemic lupus erythematosus. The Ro protein has been implicated in cellular RNA ...
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Vakonakis, Ioannis (Texas A&M University, 2005-08-29)Circadian oscillators or clocks are a widespread, endogenous class of oscillatory mechanisms that control the ~24h temporal pattern of diverse organism functions. In cyanobacteria this mechanism is formed by three proteins, ...
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Sobrado, Pablo (Texas A&M University, 2004-09-30)Flavocytochrome b2 catalyzes the oxidation of lactate to pyruvate. Primary deuterium and solvent kinetic isotope effects have been used to determine the relative timing of cleavage of the lactate OH and CH bonds by the ...