Browsing by Author "Hardin, Paul"
Now showing items 1-20 of 22
-
Zhou, Jian (2017-07-12)The Drosophila circadian oscillator controls daily rhythms in physiology, metabolism and behavior via transcriptional feedback loops. CLOCK-CYCLE (CLK-CYC) heterodimers initiate feedback loop function by binding enhancer ...
-
Jayant Kumar Ojha, Nikita (2016-05-06)Circadian regulation of Mitogen Activated Protein Kinase (MAPK) pathways provides a priming mechanism to allow organisms to anticipate daily environmental stresses such as heat, light, desiccation and osmotic stress. In ...
-
Liu, Tianxin (2017-07-31)In Drosophila, time-keeping is based on a ~24h transcription feedback loop, in which CLOCK-CYCLE (CLK-CYC) heterodimers activate transcription of genes encoding the feedback repressors PERIOD (PER) and TIMELESS (TIM). ...
-
Iiams, Samantha (2021-04-07)Since the dawn of life on Earth, organisms have had to overcome tremendous challenges in securing food, territory, and mates in order to survive daily and seasonal environmental fluctuations imposed by the rotation of the ...
-
Ding, Zhaolan (2021-04-22)At least half of proteins cycling in abundance under control of the circadian clock in eukaryotic cells are synthesized from non-cycling mRNAs. These data suggested that the clock controls posttranscriptional events, ...
-
Zhou, Jian; Yu, Wangjie; Hardin, Paul (PLoS Genetics, 2016)
-
Chatterjee, Abhishek (2012-07-16)Chemoreception is a primitive sense universally employed by organisms for finding and selecting food, rejecting toxic chemicals, detecting mates and offspring, choosing sites for egg-laying, recognizing territories and ...
-
Eun Young Kim; Hyuk Wan Ko; Yu, Wangjie; Hardin, Paul; Edery, Isaac (Molecular and Cellular Biology, 2007)
-
Carnahan, Mindy (2012-10-19)Sialylation is an important carbohydrate modification of glycoconjugates, which introduces sialic acids (SA). The relatively large nine-carbon, negatively charged sugars are typically located at the termini of carbohydrate ...
-
Caster, Courtney Marie (2017-07-18)Mapping the evolution of the transcriptional feedback loops that regulate the circadian clock will lead to the understanding of how this essential pacemaker allows insects to anticipate changes in their environment. ...
-
Shende, Vikram Ravindra 1982- (2012-11-15)The circadian system in mammals is arranged as a hierarchical network of oscillators, with the master pacemaker of circadian rhythms located in the suprachiasmatic nuclei (SCN) of the hypothalamus and peripheral oscillators ...
-
Yavuz, Ahmet E (2017-12-14)In contrast to mammals, which sense sweet tasting molecules through a single, dimeric sugar taste receptor, Drosophila melanogaster use at least eight sugar gustatory receptor (Gr) proteins to recognize a range of dietary ...
-
Sherlekar, Amrita Laxman (2015-05-12)In key survival behaviors like predator-prey interactions and mating, animals have to integrate dynamic sensory inputs from a moving target and regulate their motor outputs on moment-to-moment basis. The molecular underpinnings ...
-
The Origins and Phenotypic Consequences of Repetitive Sequence Variation in Drosophila melanogaster Aldrich, John C (2015-08-19)Environmental stimuli can have a significant impact on gene expression patterns and this impact is not always confined to a single cell cycle, but can sometimes persist through multiple divisions or even transgenerationally. ...
-
Womac, Alisa Diane (2012-10-19)Molecular, cellular, and physiological processes within an organism are set to occur at specific times throughout the day. The timing of these processes is under control of a biological clock. Nearly all organisms on Earth ...
-
Scott, Hilary Anne (2017-08-16)Sialylation is a common post-translational modification in animal cells, yet its molecular and cellular regulation is poorly understood. It is involved in many vital functions in vertebrates, while perturbations in sialylation ...
-
Baker, Ryan Andrew (2016-12-09)Congenital muscular dystrophies (CMD’s) are serious diseases affecting muscle, brain, eye, and other tissues and often result in premature death of patients. These forms of muscular dystrophy are largely underlain by defects ...
-
Ramirez, Manuel Antonio (2021-04-22)The circadian clock is a conserved endogenous time keeping mechanism that controls up to half of the eukaryotic genome at the level of transcript abundance. In addition to clock control of transcript abundance, our lab ...
-
Chen, Xin (2016-11-23)In response to altered physiological demands, cardiac muscles remodel their muscle mass and contractile properties to sustain muscle performance. However, dramatic alterations of the sarcomere structure are rarely observed ...
-
Caster, Stephen Z (2016-08-01)Stress response pathways function to allow cells to adapt to changes in the environment. In Neurospora crassa, acute osmotic stress activates the conserved p38-like osmosensing mitogen-activated protein kinase (OS MAPK) ...