Browsing by Author "Burghardt, Robert"
Now showing items 1-20 of 51
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Popp, Julia L (2021-07-26)Contemporary approaches for developing new interventions and for pre-clinical risk evaluation include assessments for cardiovascular structure and function, frequently performed in a variety of animal and in vitro models, ...
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Clubb, Aaron Bryant (2017-05-09)The purpose of this study was to explore the performance of a secondary ion mass spectrometry (SIMS) technique for probing nanovolumes. The variant of SIMS used involves bombardment with individual massive projectiles ...
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Al Muhisen, Hadil Mahdi J (2023-05-10)Spermatogenesis is a crucial process that generates fertile sperm, and it is a complex process that involves a remarkable number of proteins and molecules. However, the disruption of spermatogenesis at any stage can lead ...
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Wu, Fei (2009-05-15)Estrogen receptor α (ERα) is a ligand activated transcription factor. Many widely used synthetic compounds and natural chemicals can activate ERα. The compounds investigated in this study include 17β-estradiol (E2), ...
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Kondow-McConaghy, Helena Marie (2020-06-19)Mammalian cells are a model system for biotechnology and therapeutic development. For many of these applications, some degree of cellular manipulation is required to trigger certain biological outcomes. To achieve this, ...
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Usama, Syed Muhammad (2019-06-05)Optical imaging is most favorable for dyes that absorb in the near-IR region because tissue is more permeable to light >750 nm. A particular set of cyanine dyes localize and persists in almost all solid tumors (e.g. ...
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Sherrod, Stacy D. (2010-01-14)Imaging mass spectrometry (MS) analysis allows scientists the ability to obtain spatial and chemical information of analytes on a wide variety of surfaces. The ability to image biological analytes is an important tool in ...
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Williams, Edward Spencer (Texas A&M University, 2004-09-30)NF-κB activity is critical in the regulation of atherosclerotic vascular smooth muscle cell (vSMC) phenotypes induced following oxidative injury by allylamine. The present studies were designed to detail dysregulation of ...
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The Efficacy of Melatonin in Protecting Neural Retina and Retinal Microvasculature in Early Diabetes Chang, Ya-An (2018-10-16)Diabetic retinopathy (DR) is the leading cause of blindness among American working populations. Oxidative stress is one of the major culprits contributing to the pathogenesis of DR. In this study, we tested whether melatonin, ...
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Folcik, Alexandra Michelle (2021-09-03)Increasing global water scarcity is underscoring the need for efficient and reliable treatment technologies within the water treatment process. Ionizing radiation technologies present promising strategies for the remediation ...
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Lewis, Ruth Ellen (Texas A&M University. Libraries, 1985)The microvascular response to topical application of leukotriene B4(LTB4) in the hamster cheek pouch was investigated using a combined intravital-electron microscopic approach. In an effort to gain insight into the cellular ...
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Mukherjee, Atashi (2014-05-30)The chemical characterization of nanomaterials in the realm of drug delivery and surface modification is on the current frontiers of analytical chemistry. A drug delivery vehicle must be able to carry therapeutic cargo and ...
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Steinhauser, Chelsie Burroughs (2015-11-03)Commercial sows experience a high incidence of prenatal loss and substantial variation in birthweight among piglets in a litter. These outcomes negatively impact efficiency and profitability in the swine industry and are ...
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Gomez, Gabriel (2013-02-26)Despite being amongst the most common zoonotic diseases in the world, brucellosis is a neglected disease for which an approved vaccine for human use does not exist. Thus far, the traditional approaches to Brucella antigen ...
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Partridge, Charles Randal (Texas A&M University, 2007-04-25)Gene expression was examined in vascular smooth muscle cells to study the complex interaction between oxidative injury and the pathogenesis of vascular disease. Extensive vascular remodeling coupled to increased production ...
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Najjar, Kristina (2017-07-13)For over 20 years, cell-penetrating peptides (CPPs) have been used as delivery vectors transporting macromolecules (cargos) into live cells for cell biology manipulations and therapeutic applications. While the exact ...
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Williams, Diarra Kevin (2018-08-28)Genetic disorders associated with skeletal disease are extremely complex and vary greatly in their clinical phenotypes. Thus, in vivo models that accurately recapitulate these rare bone pathologies are essential for ...
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Inhibition of breast and prostate cancer cell growth by 3,3'-diindolylmethane and related compounds Kotha, Leela (2009-05-15)Selective receptor modulators have been developed for steroid hormone receptors as a new class of mechanism-based drugs for treatment of hormone related diseases. We investigated an alternative mechanism-based strategy ...
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Walker, Kelcey Manae Becker (Texas A&M University, 2005-08-29)The aryl hydrocarbon receptor (AhR) binds synthetic and chemoprotective phytochemicals, and research in this laboratory has developed selective AhR modulators (SAhRMs) for treatment of breast cancer. Activation of the AhR ...
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Hegde, Bharati Krishna (Texas A&M University, 2004-09-30)Information is transmitted from the cell surface to various specific targets in the cell via several cellular signaling pathways. Cytosolic free calcium (Ca2+)is one of the most versatile and ubiquitous intracellular ...