Browsing by Author "Lin, Yun"

Now showing 1 - 6 of 6
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    Aerosol vertical distribution and optical properties over China from long-term satellite and ground-based remote sensing
    (Atmospheric Chemistry and Physics, 2017) Tian, Pengfei; Cao, Xianjie; Zhang, Lei; Sun, Naixiu; Sun, Lu; Logan, Timothy; Shi, Jinsen; Wang, Yuan; Ji, Yuemeng; Lin, Yun; Huang, Zhongwei; Zhou, Tian; Shi, Yingying; Zhang, Renyi
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    Design and Development of Intricate Nanomedical Devices through Compositional, Dimensional and Structural Control
    (2012-07-16) Lin, Yun; Wooley, Karen L.; Burgess, Kevin; Cremer, Paul S.; Grunlan, Melissa A.
    Nanomedicine, the medical application of nanotechnology, uses nanoscale objects that exist at the interface between small molecule and the macroscopic world for medical diagnosis and treatment. One of the healthcare applications of nanomedicine is drug delivery: the development of nanoscale objects to improve therapeutics' bioavailability and pharmacokinetics. Shell crosslinked knedel-like nanoparticles (SCKs), that are self assembled from amphiphilic block copolymers into polymeric micelles and then further stabilized with crosslinkers isolated throughout the peripheral shell layer, have been investigated for drug delivery applications that take advantage of their core-shell morphology and tunable surface chemistry. SCKs are attractive nanocarriers because the cores of the SCKs are used for sequestering and protecting guests. The readily adjustable shell crosslinking density allows for gating of the guest transport into and out of the core domain, while retaining the structural integrity of the SCKs. Moreover, the highly functionalizable shell surface provides opportunity for incorporation of targeting ligands for enhanced therapeutic delivery. The optimization of nanoparticle size, surface chemistry, composition, structure, and morphology has been pursued towards maximization of the SCKs' therapeutic efficacy. With distinctively different dimensions, compositions and structures of the core and shell domains of SCKs, and an ability to modify each independently, probing the effects of each is one of the major foci of this dissertation. Utilization of a living radical polymerization technique, reversible addition-fragmentation chain transfer (RAFT) polymerization, has allowed for facile manipulation of the block lengths of the polymer precursors and thus resulted in various dimensions of the nanoparticles. SCKs constructed from poly(acrylic acid)-b-polystyrene (PAA-b-PS) with various chain lengths, have been investigated on the loading and release of doxorubicin (DOX). The effect of PEGylation on paclitaxel (PTX) loaded SCKs on the cell internalization and killing was investigated. Apart from chemotherapies, the SCKs were explored as antimicrobial agents by incorporating silver species. Conjugation of the SCK surface with a protein adhesin through amidation chemistry to promote epithelial cell targeting and internalization was developed. Nanoscale assemblies with complex morphologies constructed from a linear triblock copolymer was investigated. Furthermore, a highly multifunctional nanodevice for imaging and drug delivery functionalized with a chelator for radio-labeling, polyethylene glycol (PEG) for improved biodistribution, targeting ligands, a chromophore and a therapeutic agent was evaluated in vivo as active-targeted delivery of therapeutics.
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    Functional, cross-linked nanostructures for tandem optical imaging and therapy
    (United States. Patent and Trademark Office, 2017-05-30T00:00:00Z) Neumann, William L.; Dorshow, Richard B.; Freskos, John N.; Wooley, Karen L.; Lee, Nam S.; Lin, Yun; Sun, Guorong; Mallinckrodt LLC; Washington University; The Texas A&M University System
    The present invention provides optical agents comprising optically functional cross linked supramolecular structures and assemblies useful for tandem optical imaging and therapy. Supramolecular structures and assemblies of the present invention include optically functional shell-cross linked micelles wherein optical functionality is achieved via incorporation of one or more linking groups that include one or more photoactive moieties. The present invention further includes imaging and therapeutic methods using one or more optical agents of the present invention including optically functional shell cross-linked micelles having an associated therapeutic agent.
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    Functional, cross-linked nanostructures for tandem optical imaging and therapy
    (United States. Patent and Trademark Office, 2016-03-29) Neumann, William L.; Dorshow, Richard B.; Freskos, John N.; Wooley, Karen L.; Lee, Nam S.; Lin, Yun; Sun, Guorong; Mallinckrodt LLC; The Texas A&M University System; Washington University
    The present invention provides optical agents comprising optically functional cross linked supramolecular structures and assemblies useful for tandem optical imaging and therapy. Supramolecular structures and assemblies of the present invention include optically functional shell-cross linked micelles wherein optical functionality is achieved via incorporation of one or more linking groups that include one or more photoactive moieties. The present invention further includes imaging and therapeutic methods using one or more optical agents of the present invention including optically functional shell cross-linked micelles having an associated therapeutic agent.
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    Persistent sulfate formation from London Fog to Chinese haze
    (Proceedings of the National Academy of Sciences of the United States of America, 2016) Wang, Gehui; Zhang, Renyi; Gomez, Mario; Yang, Lingxiao; Misti Levy Zamora; Hu, Min; Lin, Yun; Peng, Jianfei; Guo, Song; Meng, Jingjing; Li, Jianjun; Cheng, Chunlei; Hu, Tafeng; Ren, Yanqin; Wang, Yuesi; Gao, Jian; Cao, Junji; An, Zhisheng; Zhou, Weijian; Li, Guohui; Wang, Jiayuan; Tian, Pengfei; Marrero-Ortiz, Wilmarie; Secrest, Jeremiah; Du, Zhuofei; Zheng, Jing; Shang, Dongjie; Zeng, Limin; Shao, Min; Wang, Weigang; Huang, Yao; Wang, Yuan; Zhu, Yujiao; Li, Yixin; Hu, Jiaxi; Pan, Bowen; Cai, Li; Cheng, Yuting; Ji, Yuemeng; Zhang, Fang; Rosenfeld, Daniel; Liss, Peter; Duce, Robert; Kolb, Charles; Molina, Mario
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    Regional Microphysical and Radiative Effects of Aerosols
    (2018-05-05) Lin, Yun; Zhang, Renyi; Collins, Donald; Schumacher, Courtney; Ying, Qing
    In this study, the regional-scale aerosol effects are quantitatively assessed under various weather conditions by conducting numerical modeling studies to improve the understanding of physical processes involved in aerosol-cloud and aerosol-radiation interactions. A continental cloud complex consisting of three cloud regimes is simulated by the Weather Research and Forecast (WRF) model to investigate the aerosol microphysical effect (AME) and aerosol radiative effect (ARE). The results reveal that the responses of three cloud regimes to aerosols are jointly controlled by AME and ARE. The aerosol effects on the cloud complex are distinct from its individual cloud regime, highlighting that aerosol-cloud interactions for diverse cloud regimes and their transitions need to be carefully evaluated. The increasingly severe regional haze in China is associated with a high ratio of oxygenated organic aerosol over odd-oxygen concentrations during clean-to-hazy transition periods, corresponding to intensive photochemical activities in Beijing. Modeling studies using WRF with an aerosol radiative module indicate that the aerosol-planetary boundary layer interactions during severe haze might trigger a positive feedback loop to amplify PM pollution. The small negative forcing at top of atmosphere (TOA) by the heavy loading PM is a result of the strong cooling largely canceled out by the strong heating. The aging of black carbon can contribute significantly to the total PBL collapse and the total BC TOA forcing. The impacts of aerosols on a hurricane with ocean coupling is studied by using the WRF coupled with Regional Ocean Model System. The aerosol effect causes an expansion of storm circulation at the cost of the intensity. The aerosol-induced feedback of ocean coupling shows an appreciable influence on the mature storm. The storm destructiveness tends to be exacerbated by the aerosol effect due to the circulation expansion and corresponding structure modulations under polluted condition.