University Undergraduate Research Fellows (1968–2012)
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Browsing University Undergraduate Research Fellows (1968–2012) by Author "[Klemm, W. R.]"
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Item The Role of Dopaminergic Mechanisms in Acute Naloxone-Precipitated Morphine Withdrawal(1981) Roper, Steve; [Klemm, W. R.]Definite similarities have been observed between the motor effects of morphine and activities mediated by dopaminergic systems in the brain. Dopamine systems are known to mediate such responses as stereotypic behavior, hyperactivity, and catalepsy. Two drugs were used in this study to alter dopaminergic activity: apomorphine and haloperidol. Apomorphine is a dopamine agonist. This means that it stimulates dopamine receptors. Haloperidol is a dopamine antagonist meaning that it inhibits dopamine receptors. Both morphine and apomorphine can produce hyperactivity and stereotyped behaviors. Both haloperidol and morphine can produce catalepsy. Because of the similarities in motor effects between morphine and drugs which alter dopaminergic activity it became reasonable to theorize over-lapping mechanisms for the two systems. From this we arrived at the objective if this project: to see if drugs which alter dopaminergic activity would have an effect on acute naloxone-precipitated hyperactivity.