Mapping The Bovine Cystic Fibrosis Gene
Abstract
Human cDNA probe H1. 6 (clone 10-1) encoding cystic fibrosis transmembrane conductance regulator (CFTR) was used to map the bovine homolog of CFTR. Using a panel of bovine X rodent hybrid somatic cells, the homolog was mapped to bovine syntenic group U13. CFTR is 97.7% concordant with syntenic markers T-cell receptor beta (TCRB) and P-glycoprotein 3 (PGY3) previously mapped on U13. The comparative gene maps of CFTR, TCRB, and PGY3 on human chromosome 7, bovine syntenic group U13, and mouse chromosomes 5 and 6 indicate considerable evolutionary conservation.
Description
Program year: 1992/1993Digitized from print original stored in HDR
Subject
cystic fibrosiscystic fibrosis transmembrane conductance regulator
bovine
bovine syntenic group U13
Citation
Wallis, Deeann (1993). Mapping The Bovine Cystic Fibrosis Gene. University Undergraduate Fellow. Available electronically from https : / /hdl .handle .net /1969 .1 /CAPSTONE -WallisD _1993.