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Studies of highly functionalized bicyclic ring systems directed towards the total synthesis of [(positive or negative symbol)]-vernolepin
(1986)
Highly functionalized derivatives of the bicyclo[4.3.1]-dec-3-ene (1) ring system were examined as part of an effort to synthesize the sesquiterpene (+)-vernolepin (2). Although vernolepin has been synthesized in other ...
Enzymes in organic synthesis
(1987)
Several aspects of the use of enzymes as catalysts in organic synthesis have been explored. The stability of the enzyme glucose dehydrogenase useful in reduced nicotinamide cofactor (NAD(P)H) regeneration has been studied. ...
Ionization and fragmentation of molecular gases in collisions with MeV/amu heavy ions
(1988)
A detailed study of ionization and fragmentation in molecular gas targets by 2.75 MeV H[+] and 40 MeV Ar[13+] ions has been performed using the time-of-flight (TOF) method. Ionization of molecular gases by 2.75 MeV H[+] ...
A new method for kinetic studies of fast radical rearrangements : development and applications
(1989)
An indirect method for studying the kinetics of fast radical rearrangements has been developed. The method employs N-hydroxypyridine-2-thione ("PTOC") esters as radical precursors and hydrogen atom transfer from thiophenol ...
Syntheses of linear tetrapyrroles as potential inhibitors for uroporphyrinogen III synthase
(1992)
Living systems depend on a variety of metal complexes of tetrapyrrolic macrocycles to carry out many biologically important functions. Among these pigments of life are heme, chlorophyll and vitamin B[12]- All these substances ...
Characterization of organic species on solid surfaces using ²⁵²cf plasma desorption mass spectrometry
(1989)
Cf-252 plasma desorption mass spectrometry (PDMS) has been applied to the characterization of compounds which are difficult to analyze by conventional mass spectrometry. These included organic dyes (individual and mixtures) ...
Synthesis of substrates and analogs for the enzymes of vitamin B₁₂ biosynthesis
(1990)
The synthesis of some of the postulated intermediates in the pathway of vitamin B12 biosynthesis, precorrins-4A, -4B and -5, were initiated. The different ring precursors necessary for the precorrins were prepared as racemic ...
Enzyme catalyzed oxido-reductive reactions : synthetic applications and mechanistic studies
(1992)
Chapter II describes the synthetic application of a non-heme monooxygenase from Pseudomonas oleovorans (POM) toward the preparation of a series of epoxides from their protected allylic alcohol precursors. Like other ...
Discovery of a labile nickel ion required for CO/acetyl-CoA exchange activity in the NiFe complex of carbon monoxide dehydrogenase
(1992)
The oxygen-sensitive, nickel and iron-containing enzyme carbon monoxide dehydrogenase (CODH) from clostridium thermoaceticum was purified without any significant loss of the activity present in the crude extract. The careful ...